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FLASH GENE
Symbol ATP10D contributors: mct - updated : 30-06-2021
HGNC name ATPase, Class V, type 10D
HGNC id 13549
DNA
TYPE functioning gene
STRUCTURE 108.21 kb     23 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
23 - 6668 160.2 1426 - 2013 24125428
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver     Homo sapiens
Nervousbrain     Homo sapiens
Reproductivemale systemprostate   
 male systemtestis    Homo sapiens
Respiratorylung    
Urinarykidney     Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • cation transport atpases family (p-type atpases)
  • subfamily IV
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in the active transport of charged substrates across biological membranes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to elevated levels of glucosylceramide (GlcCer) in plasma
    Variant & Polymorphism SNP
  • ATP10D SNPs are associated with elevated levels of glucosylceramide (GlcCer) in plasma from diverse European populations
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • deficiency of Atp10a and Atp10d leads to insulin resistance and obesity in mice