protein
| CBX1 |
|
binding to the 501-900-amino acid region of CABIN1 |
|
interacting with SIRT1 (functional link between the heterochromatin-related histone methyltransferase SUV39H1 and the histone deacetylase SIRT1) |
|
interacting with ESCO2 |
|
EVI1 directly interacts with SUV39H1 and the proteins form an active complex with methyltransferase activity |
|
KIAA1967 binds to the SUV39H1 catalytic domain and inhibits its ability to methylate histone H3 |
|
interaction with BCL11B (constitutive CDKN1A gene suppressor that cooperates with SUV39H1 and histone methylation to silence the CDKN1A gene transcription) |
|
targeted to TP53 target promoters by binding MDM2 acidic domain and neutralizing its TP53 conformational effect, forming a TP53-MDM2-SUV39H1 complex capable of DNA binding and transcription repression |
|
interaction with SIRT1 (SIRT1 controls global levels of SUV39H1 by increasing its half-life through inhibition of SUV39H1 lysine 87 polyubiquitination by the E3-ubiquitin ligase MDM2) |
|
UHRF1 might interact with SUV39H1 and, through this interaction, direct the recruitment of SUV39H1 to gene promoters |
|
KLF11 recruits CBX5 and its histone methyltransferase, SUV39H1, to promoters to limit KLF11-mediated gene activation |
|
MECOM and PRDM16 initiate heterochromatin formation by inducing cytoplasmic H3K9me1, which is then converted in the nucleus by the SUV39H1 enzymes to H3K9me3 |
|
specific role for CBX1, CBX3, CBX5 in regulating SUV39H1 function under stress via a feedback mechanism that likely regulates heterochromatin formation |
|
DCAF13 interacts with SUV39H1 |