SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,nucleus,nucleolus
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text
| localizes at interphase centrosomes, where it accumulates following DNA damage or spindle poisons |
basic FUNCTION
| involved in the regulation of gene transcription and cell proliferation |
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inhibiting the RB growth-suppressing function by interfering with RB-mediated HDAC1 recruitment on E2F target gene promoters |
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acting as HDAC1 competitor (by displacing HDAC1 from the CDKN1A promoter) and its down-regulation is involved in colon carcinoma cell proliferation |
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contributing to the maintenance of the G2/M checkpoint induced by DNA damage |
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transcriptionally activates AKT1 gene through STAT3, which sustains KT1 activation and promotes cell survival |
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RNA polymerase II binding protein involved in the regulation of gene transcription and, in response to DNA damage, promotes TP53 transcription |
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important role in survival of cells expressing mutant TP53 |
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nucleolar stress sensor, which is required as a cofactor for JUN-mediated apoptosis |
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activating XIAP expression in response to DNA damage |
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plays an important role in DNA damage response (DDR) and its contribution seems to be relevant for the spindle assembly checkpoint |
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involved in transcriptional regulation, cell cycle control, DNA damage responses and in the execution of cell death programs |
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RNA polymerase II-binding protein that is involved in the regulation of gene transcription, which undergoes stabilization and accumulation in response to DNA damage |
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important role in the cellular response to DNA damage |