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FLASH GENE
Symbol ACAP1 contributors: mct - updated : 27-04-2015
HGNC name ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
HGNC id 16467
DNA
TYPE functioning gene
STRUCTURE 14.92 kb     22 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 2523 81.4 740 - 2000 11062263
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus   highly
Endocrineadrenal gland   highly
Lymphoid/Immunelymph node   highly
 tonsils   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a pleckstrin homology (PH) domain
  • three ankyrin repeats (ANK)
  • a ARF-GTPase protein analogous domain
  • a BAR domain, that can neither bind membrane nor impart curvature, but instead requires the neighboring PH (Pleckstrin Homology) domain to achieve these functions
  • HOMOLOGY
    Homologene
    FAMILY
  • centaurin family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text cell periphery, tubular membranes (site of membrane recycling)
    basic FUNCTION
  • ARF(6)-GTPase activating protein, controlling the return of Arf to the inactive GDB-bound shots
  • ARF6 GAP that also acts as a key component of a recently defined clathrin complex for endocytic recycling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • part of a novel clathrin coat complex that is regulated by ARF6 for endocytic recycling in two key physiological settings, stimulation-dependent recycling of integrin that is critical for cell migration and insulin-stimulated recycling of SLC2A1, which is required for glucose homeostasis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GULP1 is a modifier of cellular ARF6-GTP through regulation of ACAP1
  • oncogenic potential of USP6 is linked to its ability to integrate cell migration and cytokinesis by regulating ARF6/ACAP1
  • ARF6 inactivation by expression of ACAP1 leads to increased recycling of ITGB1 to the neuronal surface and to increased anterograde axonal transport
  • ARAP2 and ACAP1 had opposing effects on apparent ITGB1 internalization
  • cell & other
  • targeted by phosphatidyl inositol (3,4,3) triphosphate, inhibiting the formation of PDGF-induced dorsal membrane ruffles in NIH 3T3 fibroblasts, when overexpressed
  • REGULATION
    Other
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS