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FLASH GENE
Symbol CTAG2 contributors: - updated : 02-11-2004
HGNC name cancer/testis antigen 2
HGNC id 2492
DNA
TYPE functioning gene
STRUCTURE 1.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
alternative promoter
cytosine-phosphate-guanine/HTF
text structure two ATGs,CpG rich promoter
MAPPING cloned Y linked N status confirmed
regionally located in the NEMO/LAGE cluster
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 7550 - 180 - Lethe
- splicing 1002 21 210 - Lethe
exon 1 joined to exon 2
- - 680 - 109 - Aarnoudse
- - 990 - - - -
alternative frame starting from the second ATG
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentmelanocyte
cell lineage
cell lines melanoma cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two glycine-rich regions
  • a hydrophobic stretch near the C-terminus
  • HOMOLOGY
    intraspecies homolog to CTAG1B
    Homologene
    FAMILY NY-ESO-1 family
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION tumor antigen that may serve as a target for immunotherapy
    CELLULAR PROCESS cell life
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by deoxy-azacytidine in lymphoblastoic cells
    inhibited by silenced by DNA methylation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS