SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,inner
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| intracellular,cytoplasm,organelle,mitochondria,outer
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,nucleus
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text
| distributions of clusters of TOMM20 and of TOMM22 follow an inner-cellular gradient from the perinuclear to the peripheral mitochondria |
basic FUNCTION
| mitochondrial import receptor having chaperone-like activity |
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import receptor and organizer of the TOM complex involved in protein translocation into mitochondria and has a dual role, as it is a component of the general insertion pore together with the pore-forming protein TOMM40 and, as such, is involved in protein translocation across the mitochondrial outer membrane |
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apparently involved in the same step or sequential steps along the same pathway of targeting signal recognition in import as TOMM20, but may recognize opposite sides of the same presequence in the same step (TOMM20 recognizing the hydrophobic surface and TOMM22 the hydrophilic surface) |
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is a critical regulator of steroidogenesis, and thus, it is essential for mammalian survival |