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FLASH GENE
Symbol PEX14 contributors: mct/npt - updated : 01-02-2015
HGNC name peroxisomal biogenesis factor 14
HGNC id 8856
DNA
TYPE functioning gene
STRUCTURE 155.81 kb     9 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1945 41.2 377 - Olsen (2006)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestine   
 mouthtongue  highly
 pancreas exocrine   moderately
Reproductivefemale systemplacenta  highly
 female systemuteruscervix moderately
 female systemovary  highly
Respiratorylung   highly
Skin/Tegumentskin   moderately
Urinarybladder   moderately
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid Hydrophobic
STRUCTURE
motifs/domains
  • N-terminal domain mediating molecular interactions with PEX5 and PEX19, and modulating peroxisomal targeting of PEX14
  • an aspartic-acid and glutamic acid rich region
  • a non-membrane hydrophobic region
  • a coiled-coil region
  • a charged acidic C terminus
  • a single putative transmembrane domain
  • C-terminal two-thirds are exposed into the cytosol, whereas its N-terminal domain is either embedded in the peroxisomal membrane or even exposed into the matrix of the organelle
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to rattus Pex14
    ortholog to murine Pex14
    Homologene
    FAMILY
  • peroxin 14 family
  • CATEGORY regulatory , storage
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    text
  • intrinsic peroxisomal membrane protein
  • outer face
  • basic FUNCTION
  • involved in the transcription regulation of specific erythroid and megakaryocytic gene
  • putative docking protein for PEX5, the peroxisomal cycling receptor
  • multi-tasking protein that not only facilitates peroxisomal protein import but is also required for peroxisome motility by serving as membrane anchor for microtubules
  • role of PEX14 in the release of cargo proteins into the peroxisomal matrix
  • essential import receptors PEX3 and PEX14 target mitochondria, where they are selectively released into vesicular pre-peroxisomal structures
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the peroxisomal translocation machinery with PEX13 and PEX17
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PEX13 (SH3 protein domain), putative docking protein for PTS1-dependent protein import, with HDAC1
  • central component of the peroxisomal import machinery and binds the soluble receptors PEX5 and PEX19
  • tubulin was discovered to be the major PEX14-associated protein
  • N-terminal region in PEX26 acts as a scaffold protein to recruit PEX14·PEX5 complex together with PEX1·PEX6 complexes on peroxisomes
  • in the peroxisomal protein import, AAA peroxins modulate the interaction between PEX26 and PEX14 on peroxisome membrane as well as PEX5 oligomer in the cytosol
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PBD10
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in favorable subset of primary neuroblastoma
    tumoral     --low  
    in unfavorable subset of primary neuroblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS