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FLASH GENE
Symbol TRIM3 contributors: mct - updated : 11-09-2010
HGNC name tripartite motif-containing 3
HGNC id 10064
DNA
TYPE functioning gene
STRUCTURE 25.36 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 splicing 3059 80.7 744 - El Husseini (2001)
also called variant 1/isoform alpha
12 splicing 2894 80.7 744 - El Husseini (2001)
also called variant 2/isoform beta
- splicing 2023 72 665 - El Husseini (2001)
also called variant 3/isoform gamma
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   moderately
Nervousbrainhindbraincerebellum predominantly
Reproductivefemale systemuteruscervix moderately
 female systembreastmammary gland highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal RING zinc finger
  • a B box domain type 1 and type 2
  • linked to a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • two zinc binding domains
  • a C terminal B30-2
  • RFP-like domain
  • six NHL repeats
  • a filamin repeat
  • conjugated
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to rattus Trim3
    ortholog to murine Trim3
    Homologene
    FAMILY
  • TRIM/RBCC family
  • CATEGORY motor/contractile , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text growth cone
    basic FUNCTION
  • organelle transport and neurite outgrowth
  • putatively anchoring MYO5A in particular cell domains via its interaction with alpha actinin 4, ACTN4
  • E3 ligase that mediates activity-dependent turnover of PSD scaffold proteins and is a negative regulator of dendritic spine morphology (Hung 2010)
  • may act at a posttranscriptional level to regulate the intracellular trafficking of GABAA receptor (Cheung 2010)
  • unique TP53-regulated gene that modulates seizure susceptibility and GABAAR cell surface expression (Cheung 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , locomotion , cellular trafficking transport , neurogenesis
    text transport of organelles
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • tail domain of myosin Va
  • alpha actinin 4 (ACTN4)
  • specific E3 ubiquitin ligase for the PSD scaffold GKAP1/DLGAP1 (Hung 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    frequently deleted in several types of cancers
    tumoral   LOH    
    in malignant gliomas (Boulay 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • BERP-deficient miceexhibit increased resistance to pentylenetetrazol-induced seizures (Cheung 2010)