basic FUNCTION
| organelle transport and neurite outgrowth |
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putatively anchoring MYO5A in particular cell domains via its interaction with alpha actinin 4, ACTN4 |
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E3 ligase that mediates activity-dependent turnover of PSD scaffold proteins and is a negative regulator of dendritic spine morphology (Hung 2010) |
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may act at a posttranscriptional level to regulate the intracellular trafficking of GABAA receptor (Cheung 2010) |
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unique TP53-regulated gene that modulates seizure susceptibility and GABAAR cell surface expression (Cheung 2010) |