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FLASH GENE
Symbol CLK4 contributors: - updated : 29-08-2006
HGNC name CDC-like kinase 4
HGNC id 13659
DNA
TYPE functioning gene
STRUCTURE 24.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
B4GALT7 5q35.2-q35.3 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I) LOC202181 5q35.3 hypothetical protein LOC202181 NY-REN-7 5q35.3 NY-REN-7 antigen LOC391855 5 similar to olfactory receptor MOR126-1 LOC389349 5 hypothetical gene supported by NM_032361 LOC285647 5q35.3 similar to FLJ00052 protein PROP1 5q11.2 prophet of Pit1, paired-like homeodomain transcription factor LOC389350 5 similar to KIAA0752 protein LOC285658 5q35.3 similar to 60S ribosomal protein L19 N4BP3 5q35.3 similar to 60S ribosomal protein L19 FLJ22318 5q35.3 hypothetical protein FLJ22318 NOLA2 5q35 nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs) GMCL 5q35.3 germ cell-less homolog (Drosophila) HNRPAB 5q35.3 heterogeneous nuclear ribonucleoprotein A/B MGC15875 5q35.3 hypothetical protein MGC15875 COL23A1 5q35.3 collagen, type XXIII, alpha 1 MRPL50P3 5p12 collagen, type XXIII, alpha 1 CLK4 5q35 CDC-like kinase 4 ZNF354A 5q35.3 zinc finger protein 354A LOC391856 5 similar to acetoacetyl-CoA synthetase; acetoacetate-CoA ligase; homolog of C. elegans supressor of ras 5 (sur-5) LOC391857 5 similar to hypothetical protein MGC2574 ZNF354B 5q35-3 zinc finger protein 354B LOC340042 5q35.3 similar to hypothetical protein MGC48972 PIGFP1 5q35 phosphatidylinositol glycan, class F, pseudogene 1 FLJ21628 5q35.3 hypothetical protein FLJ21628 ZNF454 5q35.3 zinc finger protein 454 GRM6 5q35 glutamate receptor, metabotropic 6 LOC391858 5 similar to F-box and WD-40 domain protein 2 LOC345462 5q35.3 similar to hypothetical protein 9630041N07 ZNF354C 5q35.3 zinc finger protein 354C LOC345463 5q35.3 similar to UNR protein ADAMTS2 5q23 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2 LOC391859 5 similar to Tb-291 membrane associated protein LOC389351 5 similar to 6-pyruvoyl-tetrahydropterin synthase RUFY1 5q35.3 RUN and FYVE domain containing 1
RNA
TRANSCRIPTS type messenger
text
  • multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2000 - - heart, muscle, kidney, liver Schultz
    - - splicing 2800 - - heart,muscle,kidney Schultz
    - - splicing 4500 - - kidney, liver, heart Schultz
    - - - 2524 57 481 - Schultz
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus   highly
     liver   highly
    Nervousbrain    
    Urinarykidney    
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  predominantly
    Muscular   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text highly in umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to rattus Clk4 (97.5pc)
    ortholog to murine Clk4 (97.1pc)
    ortholog to chicken CLK4 (83.6pc)
    Homologene
    FAMILY
  • CDC2/CDC28-like kinase family
  • Ser/Thr protein kinase family
  • Lammer subfamily
  • CATEGORY enzyme , receptor membrane
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • phosphorylating serine- and arginine-rich proteins of the spliceosomal complex
  • may be a constituent of a network of regulatory mechanisms that enable serine- and arginine-rich proteins to control RNA splicing
  • required for the regulation of alternative splicing of MAPT/TAU
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting with and inducing the nuclear redistribution of SR proteins SFRS* (see symbols)
  • UBL5
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS