protein
| dimerize with ARNT ( |
|
MOP3 ( |
|
SRC-1 and transcription intermediary factor 2, TIF2 ( |
|
von Hippel-Lindau tumor suppressor protein, VHL |
|
proteasome (prosome, macropain) subunit, alpha type, PSMA7 ( |
|
tumor suppressor TP53 ( |
|
Jun activation domain-binding protein-1, JAB1 |
|
period homolog 1 (Drosophila), PER1 ( |
|
functionally cooperates with c-Jun ( |
|
p53 binding protein homolog (mouse), MDM2 ( |
|
Brahma, Brm and Brahma/SWI2-related gene 1, Brg-1 ( |
|
SMT3 suppressor of mif two 3 homolog 1, SUMO1 ( |
|
cysteine-histidine-rich 1, CH1 ( |
|
retinoblastoma protein, pRB ( |
|
osteosarcoma amplified 9, endoplasmic reticulum lectin, OS9 ( |
|
pVHL-interacting deubiquitinating enzyme 2, VDU2 ( |
|
necdin homolog (mouse), NDN ( |
|
ARD1 ( |
|
MSF-A ( |
|
metastasis-associated protein 1, MTA1 ( |
|
testis specific gene antigen 10, TSGA10 ( |
|
beta-catenin ( |
|
spermidine/spermine-N(1)-acetyltransferase 2, SSAT2 ( |
|
RACGAP1 (HIF-1alpha function is negatively affected by its interaction with RACGAP1) |
|
Nur77 ( |
|
signal transducer and activator of transcription3, STAT3 ( |
|
ELL and HIF1A are binding partners and can modulate the functions of each other in hypoxia (PMID; |
|
Reptin |
|
PPP3R1 binds to proteasome subunit alpha type 7 (PSMA7) and inhibits the transactivation activity of HIF1A via the proteasome pathway |
|
MCM2, MCM5, MCM3 and MCM7 |
|
via its conserved D-domain, HIF1A could serve as a platform for MAPK1 in the nucleus of the cell, thus potentially facilitating phosphorylation of other MAPK1 substrates |
|
HDAC4 regulates HIF1A protein acetylation and stability, via HIF1A N-terminal lysines |
|
USP19 interacts with components of the hypoxia pathway including HIF1A and rescues it from degradation independent of its catalytic activity |
|
up-regulated the mRNA and protein expressions of HIF1A- and HIF1-targeted genes, and ADM up-regulated the protein expressions of HIF1A through down-regulation of PH4TM mRNA expression and PH4TM activity |
|
interrelationship between MUC1–HIF1A oncogenic signaling networks serves to facilitate tumor growth and metastasis |
|
E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1A |
|
control of HIF1A by STAT1 and STAT3 is an important mechanism by which VEGFA expression is regulated in smooth muscle cells (SMC) |
|
direct link between TGM2, NFKB1, and HIF1A, demonstrating TGM2 important role in cancer progression |
|
SOCS3 is identified as a novel HIF1A target gene (HIF1A suppressed the expression of adiponectin through a SOCS3-STAT3 pathway) |
|
HIF1A activates expression of genes encoding collagen prolyl (P4HA1 and P4HA2) and lysyl (PLOD2) hydroxylases |
|
mechanistic link between HIF1A and CDK8, two potent oncogenes, in the cellular response to hypoxia |
|
ESR1 plays a crucial role in decreasing HIF1A protein levels in osteoclasts, even in hypoxic conditions ( |
|
HEXIM1 attenuated the interaction of HIF1A with HDAC1 (histone deacetylase 1), resulting in acetylation of HIF1A |
|
HIF1A is transcriptional regulator of ADORA2B during acute lung injury |
|
positively regulates the induction of NFAT5 and HSPA4 by placental hypoxia |
|
MME up-regulation might be an adaptive response to hypoxia, which was mediated by HIF1A binding to HDAC1 at the early stage of hypoxia |
|
HIF1A directly regulated LEPR expression in pancreatic cancer, which might be a valuable therapeutic target for pancreatic cancer |
|
deubiquitinase OTUD7B regulates HIF1A homeostasis |
|
VHL mediate the ubiquitination of HIF1A in the nuclear compartment prior to HIF1A exportation to the cytoplasm, and VHL dynamic nuclear-cytoplasmic trafficking is indicated to be involved in the process of HIF1A degradation |
|
regulation of ATP13A2 via EGLN1-HIF1A signaling is critical for cellular iron homeostasis |
|
role of ALDOA in pancreatic cancer might attribute to its regulation of MYC, HIF1A and NFE2L2 (Nuclear Factor, Erythroid 2-Like 2), which were key regulators of glycolysis and antioxidant response control |
|
FGF11 increased HIF1A stability by acting upstream of proteasomal degradation |
|
hypoxic conditions promote TGFB1 signaling in a HIF1A-dependent manner and BAMBI is identified in this pathway as a novel HIF1A-regulated gene that contributes to hypoxia-induced loss of epithelial polarity |
|
HIF1A acts as a direct repressor of aspartate biosynthesis involving the suppression of several key aspartate-producing proteins, including cytosolic GOT1 and mitochondrial GOT2 |
| Hif1a-/- mouse embryos with complete deficiency of HIF-1alpha due to homozygosity for a null allele at the Hif1a locus die at midgestation, with multiple cardiovascular malformations and mesenchymal cell death ( | |
transgenic mice expressing constitutively active HIF-1alpha in epidermis displayed hypervascularity with 66% increase in dermal capillaries, a 13-fold elevation of total vascular endothelial growth factor (VEGF) expression, and a six- to ninefold induction of each VEGF isoform ( |
|
partialHIF-1 alpha deficiency has a dramatic effect on carotid body neural activity and ventilatory adaptation to chronic hypoxia in Hif1a(+/-) mice ( |
|
neural cell-specific HIF-1alpha-deficient mice exhibit hydrocephalus accompanied by a reduction in neural cells and an impairment of spatial memory ( |
|
skeletal-muscle HIF-1alpha knockout mice have an altered exercise endurance ( |
|
mice lacking HIF-1alpha in their myeloid cell lineage showed decreased bactericidal activity and failed to restrict systemic spread of infection from an initial tissue focus ( |
|
mice lacking HIF-1alpha in osteoblasts had impaired angiogenesis and bone healing ( |
|
HIF-1alpha- and TWIST-null mice show similarities in their phenotypes (Yang, 2008) |