basic FUNCTION
| stimulating a phosphotyrosine phosphatase which inhibits guanylate cyclase |
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having a physiological role in mechanisms of water intake and fluid retention and suggest an anti-diuretic effect of apelin (Roberts 2009) |
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APLN/APLNR system functions as a critical mediator of cardiovascular homeostasis and is involved in the pathophysiology of cardiovascular diseases. |
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BDKRB1, APLNR are involved in a variety of important physiological processes, which share many similar characteristics in distribution and functions in the cardiovascular system |
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APLN/APLNR axis is involved in hypoxia-induced proliferation of Endothelial progenitor cells (EPCs) |
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plays a prominent role in the cardiomyocyte adapting to hypertrophic stimulation |
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APLN and APLNR may play a role in human follicular development and the pathogenesis of polycystic ovary syndrome (PCOS) |
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APELA-APLNR axis protects from pressure overload-induced heart failure possibly via suppression of ACE expression and pathogenic angiotensin II signalling |
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spinal apelin& |
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8209;APLNR system may drive neuropathic pain |
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apelin/APLNR system plays a pivotal role in mediating the function of Vascular smooth muscle cell (VSMC) |
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plays an important role in aging |
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appears to be involved in regulation of renin-angiotensin-aldosterone system (RAAS), apoptosis, inflammation and oxidative stress which promotes aging |
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system plays diversified functions and regulatory roles in digestive physiology and pathology |
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APLNR signaling could be a migration related regulatory mechanism in cancer and wound healing |
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essential gene for cancer immunotherapy |
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induces vasodilation and vasoconstriction in blood vessels( |
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AGTR1 and APLNR are mechanosensitive GPCRs in the heart, playing vital roles in cardiac physiological adaptation to changes in mechanical load |
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APELA-APLNR axis is essential for diverse biological processes and has been shown to regulate fluid homeostasis, myocardial contractility, vasodilation, angiogenesis, cellular differentiation, apoptosis, oxidative stress, cardiorenal fibrosis, and dysfunction |