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FLASH GENE
Symbol TEAD4 contributors: mct/npt/pgu - updated : 22-12-2016
HGNC name TEA domain family member 4
HGNC id 11717
DNA
TYPE functioning gene
STRUCTURE 81.35 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 1780 - 434 - 2007 17652751
12 - 1651 - 391 - 2007 17652751
11 - 1525 - 305 - 2007 17652751
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Endocrinepancreas   highly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text moderatly in placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal DNA-binding TEA (TEF-1, TEC1, and AbaA) domain
  • M-CAT binding domain
  • a C-terminal YAP-binding domain (YBD)
  • HOMOLOGY
    interspecies homolog to murine Tead4
    Homologene
    FAMILY
  • TEA domain family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • lack of nuclear localization of TEAD4 impairs the trophectoderm (TE)-specific transcriptional program in inner blastomeres, thereby allowing their maturation toward the inner cell mass (ICM) lineage
  • basic FUNCTION
  • may be important for both mitogen-stimulated fibroblast proliferation and skeletal muscle cell differentiation
  • acting as a transcriptional stimulator of VEGF by regulating VEGF promoter activity through binding to Sp1 site and may play an important role in the regulation of VEGF under hypoxia
  • playing a role in the control of the transcription of the VEGF gene, in ocular vascular endothelial cells
  • playing essential roles in mediating biological functions of YAP1
  • required for RCAN-1L expression through binding to the M-CAT site in its promoter
  • required for trophectoderm development
  • early transcription factor required for specification and development of the trophectoderm lineage, which includes expression of CDX2
  • may also function to promote angiogenic response
  • plays an important role in transcriptional regulation of angiogenic genes in hypoxic endothelial cells, and key regulator of angiogenesis in response to hypoxia
  • mammalian Tead proteins regulate cell proliferation and contact inhibition as a transcriptional mediator of Hippo signaling
  • play an important role in both endothelial cells and cardiomyocytes
  • TEAD4-driven increase of VEGFB plays an important role in communication between the endothelium and myocardium
  • plays an important role in endothelial cell function by regulating angiogenesis
  • stimulates promoter activity through an insulin response element and also mediates the effects of insulin on gene expression
  • is not required for specification of the trophectoderm lineage
  • plays a crucial role in maintaining energy homeostasis during preimplantation development
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component in the Hippo pathway
  • TEAD4–YAP1 complex showing that YAP1 binds to TEAD4 through three distinct regions of its N-terminal domain
  • TEAD4-VGLL4-CTBP2 ternary complex dynamically existed at the early stage of adipogenesis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with VEGF (promoter GC-rich region containing four Sp1 response elements, located between -114 and -50,
  • essential for TEAD4 function)
  • activate NR5A1 gene expression
  • interacting with RCAN1 (RCAN1 may act as a proangiogenic factor, and therefore TEAD4 may also function to promote angiogenic response)
  • regulates the expression of HIF-1
  • acting at the promoter of the HIF1A gene to stimulate gene expression, and in turn increases the expression of downstream genes involved in angiogenesis
  • interacts with YAP1 mainly through the two short helices
  • interact with YAP1 (which lacks a DNA-binding domain but contains an activation domain) to form functional heterodimeric transcription factors that activate proliferative and prosurvival gene expression programs
  • in endothelial cells upregulates VEGFB, which is able to stimulate hypertrophic genes in cardiomyocytes
  • TEAD4-stimulated IGFBP1 expression may be central to the mechanism by which TEAD4 attenuates blood glucose levels (
  • S1PR1 is a potential target gene of TEAD4 and is involved in TEAD4-induced angiogenesis in endothelial cells
  • VGLL1-derived peptides bind to TEAD4 with nanomolar affinity
  • VGLL4 acted as an adaptor protein that enhanced the interaction between TEAD4 and CTBP2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in hypoxic endothelial cells, increasing VEGF promoter activity and VEGF expression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Tead4-/- embryos died at pre-implantation stages without forming the blastocoel