| basic FUNCTION
| role in cellular proliferation and in the lens fiber development and lymphatic system |
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specific regulator of the development of the lymphatic system and lymphatic endothelial-cell-specific transcripts |
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controlling progenitor cell proliferation and horizontal cell genesis in the retina |
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plays central roles in the differentiation of blood vascular endothelial cells (BECs) into lymphatic endothelial cells (LECs), and subsequently in the maturation and maintenance of lymphatic vessels (Harada 2009) |
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master regulator for the development of lymphatic vasculature and the induction of lymphangiogenesis (Pan 2009) |
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inhibits NOTCH1 gene expression to control the balance between neural progenitor cells (NPCs) self-renewal and neuronal differentiation  |
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occupies promoters metabolic genes and inhibits the activity of the ESRRA/PPARGC1A complex (Charest-Marcotte 2010) |
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having a role in the control of energy homeostasis (Charest-Marcotte 2010) |
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is regulated by canonical WNT signaling and has a stage-specific role in adult hippocampal neurogenesis |
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acts as a postmitotic cell fate determinant for dentate gyrus granule cells over the CA3 pyramidal cell fate and is crucial for maintenance of the granule cell identity throughout the life |
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its overexpression has the ability to reprogram venous endothelium but not early arterial endothelial cells |
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PROX1-mediated epigenetic repression is involved in the physiologically essential negative feedback inhibition of CYP7A1 transcription by bile acids |
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controls binary fate decisions between motor neurons (MNs) and V2 interneurons in neural progenitor cells (NPCs) via direct repression of OLIG2 gene regulatory elements |
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functions as a tumor suppressor gene in oral carcinogenesis |
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critical intrinsic regulator of neurogenesis in the embryonic CNS and adult dentate gyrus (DG) of the hippocampus, acting in multiple ways and instructed by extrinsic cues and intrinsic factors |
