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FLASH GENE
Symbol PDE3A contributors: mct/npt - updated : 10-09-2009
HGNC name phosphodiesterase 3A, cGMP-inhibited
HGNC id 8778
DNA
TYPE functioning gene
STRUCTURE 311.68 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 4400 1141 125 placenta Kasuya
- - - - 131 vascular, smooth muscle Choi
- - - - 118 myocardial Choi
16 - 4124 - 1141 - Hunter (2009)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
 pharynx   highly
Endocrinethyroid   highly
Reproductivefemale systembreastmammary gland highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • large hydrophobic domain at the N terminus
  • six transmembrane helices C terminal catalytic domain
  • HOMOLOGY
    interspecies homolog to murine Pde3a
    intraspecies homolog to cGMP inhibited nucleotide phosphodiesterase 3A
    Homologene
    FAMILY
  • cyclic nucleotide phosphodiesterase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • hydrolyzing both cyclic AMP (cAMP) and cyclic GMP (cGMP)
  • regulate cAMP levels in platelets, through protein kinase C-mediated phosphorylation and activation of PDE3A (Hunter 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by cAMP,cGMP
    Other activation/phosphorylation via Akt signaling pathway participates in regulating cAMP during thrombin activation of platelets (Zhang 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in failing hearts may play a causative role in the progression of heart failure, in part, by inducing CREM and promoting cardiac myocyte dysfunction (Yan 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS