Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol OAS1 contributors: mct - updated : 11-04-2018
HGNC name 2',5'-oligoadenylate synthetase 1, 40/46kDa
HGNC id 8086
DNA
TYPE functioning gene
STRUCTURE 12.97 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure
  • . ELF1 binds an important duplicated GGAA cis-acting element at the OAS1 promoter and in cooperation with RB1 and SP1 recruitment contributes to regulation in response to IFN stimulation
  • MAPPING cloned Y linked N status confirmed
    Map cen - D12S2296 - D12S2347 - D12S2344 - D12S2271 - D12S2345 - D12S1857 - D12S2253 - D12S2264 - D12S861 - D12S1616 - D12S1340 - D12S2300 - OAS1 /D12S1960 /D12S2019 - (D12S2291 - D12S2247 ),OAS3 /D12S2397 - D12S2277 - OAS2 /D12S1895 /D12S1888 - D12S2293 - D12S2292 - D12S2295 - qter
    Authors Renault (97)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1850 46 400 mitochondrial localization 2011 14559211
    8 exons very hydrophilic
    7 - 1650 41 364 - 2011 14559211
    7 exons hydrophobic C terminus
    6 - 1575 48 414 - 2011 14559211
    OAS1 I3
    - - - 44 382 - 2011 14559211
    6 - 1673 46 400 mitochondrial localization 2011 14559211
    5 - 1470 41 364 - 2011 14559211
    6 - 1614 - 360 - 2011 14559211
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Lymphoid/Immunetonsils   highly
    Reproductivefemale systembreastmammary gland highly
     female systemuteruscervix highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • oligoademylate synthase family
  • 2-5A synthetase family essential for innate immune response against viral infection
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • mediating resistance to virus infection, control of cell growth, differentiation and apoptosis
  • plays a central role in the cellular innate antiviral response
  • is one of the major interferon-inducible proteins and a critical component of the host defense system against viral infection
  • potential role of OAS1 polymorphisms in respiratory infection
  • recognizes double-stranded RNA (dsRNA) using a previously uncharacterized protein/RNA interface that forms via a conformational change induced by binding of dsRNA
  • CELLULAR PROCESS cell life, differentiation
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    nucleotide
    a component components of the innate immune response to viruses
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by interferon induced
    ASSOCIATED DISORDERS
    corresponding disease(s) PAPHG
    Susceptibility
  • host susceptibility to viral infection
  • to multiple sclerosis (MS)
  • to prostate cancer
  • to Sjögren's syndrome (SS)
  • Variant & Polymorphism SNP , other
  • influencing host susceptibility to viral infection
  • association between rs10774671 and MS
  • significant association was observed between the rs2660 genotype (A/G) and prostate cancer
  • is a risk locus for SS and support a potential role for defective viral clearance due to altered IFN response as a genetic pathophysiological basis of this complex autoimmune disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS