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FLASH GENE
Symbol NTS contributors: mct/npt - updated : 05-02-2010
HGNC name neurotensin
HGNC id 8038
DNA
TYPE functioning gene
STRUCTURE 8.70 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   cAMP
text structure
  • a proximal promoter cAMP-responsive element (CRE)/AP-1 site and a purine-rich imperfect direct repeat sequence were particularly important for expression, binding both AP-1 and CREB/ATF proteins and crucial for constitutive NTS expression
  • MAPPING cloned Y linked N status confirmed
    Map cen - D12S1708 - D12S1981 - D12S1670 - D12S319 - D12S1667 - D12S1118 - D12S1214E - D12S323 - D12S33 - D12S855 - D12S1444 - NTS - D12S81 - D12S88 - D12S365 - D12S2039 - D12S1719 - D12S1593 - KITLG - D12S1453 - (D12S2009 ,D12S1250E ) - D12S1429 - (D12S1400 ,D12S1152E ) - ATP2B1 - D12S1122 - D12S5316 - D12S82 - qter
    Authors Marondel (96),4st Workshop chrom.12 (97)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1241 13 170 - Bean (1992)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestinejejunum highly Homo sapiens
     intestinesmall intestineileum highly Homo sapiens
     stomach    
    Reproductivefemale systembreast    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion secreted
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • tridecapeptide
  • isoforms Precursor neurotensin and neuromedin N are located in the C-terminal region of the precursor (pro-NT/NN) where they are flanked and separated by three Lys -Arg sequences (Kitabgi 2009)
    HOMOLOGY
    Homologene
    FAMILY
  • neurotensin family
  • CATEGORY regulatory , signaling neurotransmitter
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • modulating dopaminergic neuronal activity
  • responsible for regulatory and trophic effets, including gut motility
  • may play an endocrine or paracrine role in the regulation of fat metabolism
  • uses PKC-dependent pathways to modulate GSK3A, GSK3B, which may play a role in the NTS regulation of intestinal cell growth (Wang 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • functions as both a neurotransmitter and a hormone through the activation of the neurotensin receptor NTSR1
  • cell & other
    REGULATION
    Other regulation of NTS expression by NR2F2, which may have important consequences for lipid metabolism
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    through two pathways during inflammatory bowel disease-related oncogenesis: one triggered by NTS overexpression, and a second associated with an activation of the APC/beta-catenin pathway (Bossard 2007)
    tumoral     --other  
    expressed in the ductal and invasive components of invasive ductal breast carcinomas (IDCs)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS