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FLASH GENE
Symbol NARS1 contributors: mct - updated : 16-09-2020
HGNC name asparaginyl-tRNA synthetase
HGNC id 7643
DNA
TYPE functioning gene
STRUCTURE 21.18 kb     14 Exon(s)
MAPPING cloned Y linked   status provisional
Map see SERPINB2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2762 - 548 - 1998 9421509
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases
HOMOLOGY
Homologene
FAMILY class II family of tRNA synthetases
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • involved in autoimmune reactions
  • is required to meet protein synthetic needs and to support radial glial cells (RGCs) proliferation in brain development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MNDDSA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS