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FLASH GENE
Symbol RAP2A contributors: mct - updated : 06-11-2014
HGNC name RAP2A, member of RAS oncogene family
HGNC id 9861
DNA
TYPE functioning gene
STRUCTURE 33.78 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
SOX21 13q31-q32 SRY (sex determining region Y)-box 21 LOC387941 13 LOC387941 LOC341583 13q32.1 similar to bromodomain containing 7; bromodomain protein; bromodomain-containing 7 LOC387942 13 LOC387942 ABCC4 13q31 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 CLDN10 13q31-q34 claudin 10 DZIP1 13q32.1 claudin 10 DNAJC3 13q32 DnaJ (Hsp40) homolog, subfamily C, member 3 UGCGL2 13q32.1 UDP-glucose ceramide glucosyltransferase-like 2 HS6ST3 13 heparan sulfate 6-O-sulfotransferase 3 LOC283476 13q32.2 hypothetical protein LOC283476 LOC390420 13 similar to heat shock protein 84 - mouse LOC341592 13q32.2 similar to tubby like protein 3 GPR80 13q32.2 G protein-coupled receptor 80 MBNL2 13q31.1 muscleblind-like 2 (Drosophila) RAP2A 13q34 RAP2A, member of RAS oncogene family LOC121906 13q32.2 similar to Proteasome subunit alpha type 6 (Proteasome iota chain) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (27 kDa prosomal protein) (PROS-27) (p27K) LOC387943 13 LOC387943 KPNB3 13q32.2 karyopherin (importin) beta 3 FARP1 13q32.2-q32.3 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) ZNF183L1 13q zinc finger protein 183-like 1 STK24 13q32 serine/threonine kinase 24 (STE20 homolog, yeast) HCP35 13q32.3 cytochrome c, somatic pseudogene SLC15A1 13q33-q34 solute carrier family 15 (oligopeptide transporter), member 1 DOCK9 13q32.1 dedicator of cytokinesis 9 LOC390421 13 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) PHGDHL1 13 phosphoglycerate dehydrogenase like 1 GPR18 13q32 G protein-coupled receptor 18 EBI2 13q32.3 Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor) LOC390422 13 similar to Epstein-Barr virus induced gene 2 TM9SF2 13q32.2 transmembrane 9 superfamily member 2 CLYBL 13q32.3 citrate lyase beta like ZIC5 13q32.2 Zic family member 5 (odd-paired homolog, Drosophila) ZIC2 13q32 Zic family member 2 (odd-paired homolog, Drosophila)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 4368 - 183 - 2006 16963453
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestine   
Lymphoid/Immunelymph node   highly
 thymus    
Nervousbrain    
Respiratoryrespiratory tractlarynx  highly
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerythroblast
Blood/Hematopoieticerythrocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Rap2a
Homologene
FAMILY Ras family of small GTP-binding proteins
CATEGORY signaling
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,endosome
intracellular,cytoplasm,cytosolic
text
  • localizing and recruiting TNIK to the recycling endosomes in a palmitoylation-dependent manner (Uechi, 2009)
  • basic FUNCTION
  • involved in small GTPase mediated signal transduction
  • playing a possible role in membrane shedding
  • functioning as a slowly responding molecular switch in the RAP1A signaling cascade
  • is a molecular link that couples the formation of microvilli in intestinal cell directly to the preceding cell polarization
  • endothelial barrier resistance is determined by the combined antagonistic actions of RAP1A and RAP2A
  • acts via TNIK to regulate the stability of LRP6 receptor for WNT/CTNNB signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • NEDD4/RAP2A/TNIK signaling pathway regulates neurite growth and arborization in mammalian neurons
  • a component
  • NEDD4, the serine/threonine kinase TNIK, and RAP2A form a complex that controls NEDD4-mediated ubiquitination of RAP2A
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ARHGAP29, putative specific effector of RAP2A to regulate RHO
  • MAP4K4 is a putative effector of RAP2A mediating the activation of JNK by RAP2A
  • by binding to phosphatidic acid enriched at the apical membrane, RAPGEF2 locally activates RAP2A resulting in induction of brush border formation via a pathway that includes the polarity players TNIK, STK26 and Ezrin
  • RAP2C is spatially segregated from RAP2A signaling as it is not enriched at the apical membrane after polarization
  • cell & other
    REGULATION
    activated by guanine nucleotide-exchange factors (GEF) EPAC,
    and EPAC2 in a cAMP-dependent manner, and GFR
    Other requires palmitoylation for membrane association and TNIK activation (Uechi, 2009)
    requires palmitoylation for induction of TNIK-mediated phenotype, the suppression of cell spreading (Uechi, 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in sporadic breast cancer, grade I
    constitutional     --low  
    age-downregulated in frontal cortex
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS