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FLASH GENE
Symbol PCCA contributors: npt/ - updated : 10-07-2006
HGNC name propionyl Coenzyme A carboxylase, alpha polypeptide
HGNC id 8653
DNA
TYPE functioning gene
STRUCTURE 441.35 kb     24 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map see COL4A1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
24 - 2518 - 728 - Campeau (1999)
23 - 2440 - 702 - Campeau (1999)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselaorta   
Digestiveintestinelarge intestinecolon highly
 liver    
Endocrineadrenal gland   highly
Nervousbrain    
Reproductivefemale systembreastmammary gland highly
 male systemprostate   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C-terminal biotin-binding domain
  • a biotin carboxylase domain, defined by homology with other biotin-dependent carboxylases
  • an ATP-GRASP domain
  • mono polymer heteromer , heptamer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • propionyl-CoA carboxylase, alpha polypeptide, biotin-dependent
  • mitochondrial conversion of propionyl CoA to methylmalonyl CoA, branched chain
  • involved in valine, isoleucine catabolism,energy pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits
  • INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • biotin
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PCCA
    related resource Propionyl CoA Carboxylase Page
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS