protein
| Npr1 gene transcription is critically controlled by histone acetyltransferase EP300 and ETS1 |
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specific receptor for atrial and brain natriuretic peptides (NPPA, NPPB) |
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PDE2A serves likely as the downstream transducer of cGMP signals produced by NPR1 activation |
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vasonatrin peptide stimulates both of the natriuretic peptide receptors, NPR1 and NPR2 |
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in the developing mammalian ventricles NPPA plays a local paracrine role in regulating the balance between cardiac progenitor cell (CPC) proliferation and differentiation via NPR1/cGMP-mediated signaling pathways |
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KLF10 acts as a transcriptional repressor of NPR1 |
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via its receptor, NPR1, NPPA maintains cardiovascular homeostasis by exerting diuretic, natriuretic, and hypotensive effects mediated, in part, by endothelial cells |
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CCM2 and PAK4 are important downstream mediators of NPPA/NPR1 signaling involved in cell spreading, an important initial step in the enhancement of endothelial barrier function |
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DPP4, AGTR2, SLC4A1, KREMEN1, ASGR1, NPR1, TMEM30A, CLEC4G, and LDLRAD3, along with ACE2 facilitate SARS-CoV-2. virus entry and transmission |