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FLASH GENE
Symbol PPY contributors: - updated : 16-02-2006
HGNC name pancreatic polypeptide
HGNC id 9327
DNA
TYPE anonymous DNA segment
STRUCTURE 1.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreasislet of Langerhans   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
EndocrinePP
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • a pancreatic polypeptide sequence separated from the pancreatic icosapeptide sequence by a cleavage site, followed by a C terminal tyrosinamide
  • isoforms Precursor 95 aa polypeptide precursor cleaved into two peptide products; the active hormone of 36 aa and an icosapeptide of unknown function
    HOMOLOGY
    Homologene
    FAMILY NPY family
    CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • regulator of pancreatic and gastrointestinal functions
  • may be important in the regulation of food intake
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS