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FLASH GENE

Symbol

LUM

contributors: mct - updated : 19-08-2011

HGNC name	lumican
HGNC id	6724

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	8.31 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002345 3 - 2116 - 338 - 1995 7665616

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Skeleton appendicular skeleton joint       Homo sapiens Skin/Tegument skin         Visual eye anterior segment cornea   highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective dense tendon     Homo sapiens Epithelial barrier/lining corneal stroma

cells

System Cell Pubmed Species Stage Rna symbol   chondrocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	ten leucine-rich repeats (LRR) flanked by cysteine-rich regions
	a N linked glycosylation site (NKSIT motifs) in the LRR region

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

small-leucine-rich proteoglycans family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	extracellular
text	extracellular matrix (ECM)

basic FUNCTION	playing a role in the regulation of collagen assembly into fibrils in various connective tissues
	having a novel regulatory role in keratocan expression at the transcriptional level
	regulating keratocan
	stimulates cell migration in the corneal epithelium by activating ERK 1/2, and point to a novel signaling pathway implicated in corneal epithelial cell migration
	plays pivotal roles in skin collagen fibrillogenesis and wound healing
	may play a key role in the generation of a new collagen network by fibroblast-like cells
	endogenous inhibitor of TGFB2 activity, resulting in downstream effector modulation including SMAD2, integrin beta1 and PTK2 to regulate osteosarcoma adhesion
	reduces tumor growth via induction of fas-mediated endothelial cell apoptosis
	efficient inhibitor of cell adhesion and migration
	affects angiogenesis both by interfering with alpha2beta1 receptor activity and downregulating proteolytic activity associated with surface membranes of endothelial cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	keratan sulfate proteoglycan one of the three major constituents of the corneal stroma
	major extracellular component of the fibrous mammalian sclera

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

repressed by

HMGA2 (transcriptionally repressed by HMGA2 and frequently lost in human high-grade serous papillary carcinoma)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast, pancreas, carcinomas, cervical carcinoma cell lines

Susceptibility

to high myopia

Variant & Polymorphism other	polymorphisms contribute to the development of high myopia

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS