SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,nucleus
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text
| co-localizes with TUBG1, centrin, and pericentrin in centrosomes, predominantly at interphase |
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unphosphorylated enzyme preferentially localizes to synaptic membranes, whereas phosphorylated GRK5 is found in plasma membrane and cytosolic fractions |
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ADRBK1, GRK5 are abundant in the nucleus of human striatal neurons ( |
basic FUNCTION
| mediating phosphatidylinositol 4,5-biphosphate (PIP2) dependent phosphorylation of beta adrenergic receptor 1 |
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inhibition of thrombin-activated phosphoinositide hydrolysis in endothelial cells |
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nuclear HDAC kinase that plays a key role in maladaptive cardiac hypertrophy apparently independent of any action directly on GPCRs |
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GRK5/6 is a novel kinases for the single transmembrane receptor LRP6 during Wnt signaling |
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role in the regulation of G-protein coupled receptor signaling |
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positive regulator of TLR4-induced NFKBIA-NFKB pathway as well as a key modulator of LPS-induced inflammatory response |
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critically involved in neurite outgrowth, dendrite branching, and spine morphogenesis through promotion of filopodial protrusion |
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separate domains of GRK5 mediated the coupling of actin cytoskeleton dynamics and membrane remodeling and were required for its effects on neuronal morphogenesis |
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crucial for proper neuronal morphogenesis and the establishment of functional neuronal circuitry |
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NFKB regulator in TLR4 signaling pathway |
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having multiple roles in TLR signaling |
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although its localization is not dependent on microtubules, it can mediate microtubule nucleation of centrosomes |
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regulates microtubule nucleation and normal cell cycle progression |
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plays a key role in cardiac signaling regulation, and its expression is increased in heart failure |
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phosphorylates Ser-4 in nucleophosmin and regulates the sensitivity of cells to PLK1 inhibition |
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is an important regulator of adipogenesis and is crucial for the development of diet-induced obesity |
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is critically involved in the regulation of lipid homeostasis in white adipose tissue |
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ADRBK1 and GRK5 control cardiac function as well as morphogenesis during development although with different morphological outcomes |
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GRK5-mediated pathological cardiac hypertrophy involves the activation of NFATC1 because GRK5 causes enhancement of NFATC1-mediated hypertrophic gene transcription |
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acting in a kinase independent manner, is a facilitator of NFATC1 activity and part of a DNA-binding complex responsible for pathological hypertrophic gene transcription |
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GRK5 plays an important functional role in negatively regulating thrombin-induced platelet reactivity |