basic FUNCTION
| deoxyribonuclease, endonuclease, involved in nuclear DNA degradation during apoptosis |
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seems to be involved in cell death by apoptosis |
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it is possible that DNASE1 plays an important role in the development of SLE nephropathy |
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DNASE1 plays an important role in the hydrolysis of double-stranded DNA and might be related to autoimmunity |
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DNASE1 is able to tolerate the generation of nonsynonymous SNPs, and the amino-acid substitutions resulting from the SNPs in DNASE1 easily alter the activity |
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is an endonuclease responsible for the destruction of chromatin during apoptosis |
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is involved in chromatin degradation of apoptotic cells |
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DNASE1 and DNASE1L3, degraded neutrophil extracellular traps (NETs), in circulation during sterile neutrophilia and septicemia |
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DNASE1 can impact HBV replication through the catabolism of the DNA genome within the capsid |
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DNASE1 has likely a role in generating short <150 bp fragments |