SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,cytoskeleton,microtubule
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| intracellular,nucleus
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text
| localised to the poles of elongated osteocyte cell bodies |
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localised to the ‘polar’ regions of elongated osteocyte cell bodies in fibula, whereas paxillin proteins are distributed more evenly across the relatively round osteocyte cell bodies in calvaria |
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cytoskeleton, cell junction, focal adhesion |
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shuttles between cytoplasm and nucleus, nuclear localization stimulating DNA synthesis and cell proliferation |
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localizes to the microtubule organizing center (MTOC) in T cells |
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LIM domain protein localized at integrin-mediated focal adhesions |
basic FUNCTION
| cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion) |
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in addition to its well established role at focal adhesions, could also be associated with the lymphocyte microtubule network |
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adaptor/scaffold protein involved in the dissemination of signals from extracellular cell adhesion proteins such as integrins and growth factor receptors |
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playing an essential role for PTPN12 inhibition of cell spreading and membrane protrusion as well as inhibition of adhesion-induced Rac activation |
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functioning as an elongated adaptor protein that links actin filaments with integrin |
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having a dual role in the HGF- and VEGF-mediated encdothelial barrier regulation |
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having a role in the modulation of Rac-Rho crosstalk |
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plays a previously unknown role as a scaffold protein of Arf guanine-nucleotide exchange factor |
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role of paxillin in facilitating attachment-independent signal transduction implicated in cancer |
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is recruited, through its LD (leucine-aspartic acid) domains, to sites of integrin engagement and may contribute to microtubule organizing center (MTOC) reorientation required for directional degranulation |
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is required for the early phase of endothelial cells (ECs) orientation in response to cyclic stretching by scaffolding for accumulation of focal adhesions (FAs) proteins |
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KCNA10, ODF2, PXN specific expression patterns imply potential functional significance in the inner ear |
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roles for PXN and TGFB1I1 in RAC1 and RHOA-dependent cell adhesion formation and maturation, processes essential for productive cell migration |
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new regulator protein of pulmonary arterial smooth muscle cells (PASMC) growth |
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focal adhesion (FA) scaffold protein that mediates integrin anchorage to the cytoskeleton, and has been implicated in regulation of FA assembly and cell migration |
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PXN variants play a prominent role in mitochondrial dynamics with direct implications on lung cancer progression |
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critical role of LIM-domain proteins PXN and zyxin in responding to mechanical stress in the actin cytoskeleton |
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negatively regulates several common platelet signaling pathways |
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controls endothelial cell migration and tumor angiogenesis by altering NRP2 expression |