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FLASH GENE
Symbol PLA2G4A contributors: mct - updated : 29-03-2016
HGNC name phospholipase A2, group IVA (cytosolic, calcium-dependent)
HGNC id 9035
DNA
TYPE functioning gene
STRUCTURE 160.08 kb     18 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 2940 85 749 - 1991 1869522
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Connective    
Epithelialbarrier/liningendothelium  
cells
SystemCellPubmedSpeciesStageRna symbol
 fibroblast
Blood/Hematopoieticneutrophil
Blood/Hematopoieticplatelet
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a N terminal calcium dependent lipid-binding/C2 domain
  • a catalytic unit differing from that of other lipases
  • HOMOLOGY
    interspecies homolog to murine pla2g4
    Homologene
    FAMILY
  • cytosolic phospholipase A2 group IV family
  • CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text translocates from cytosol and nucleus to perinuclear membrane vesicles in a calcium-dependent fashion
    basic FUNCTION
  • phospholipase A2, group IV, Ca2+ dependent
  • releasing arachidonic acid from membrane phospholipids
  • initiating the biosynthesis of prostaglandins, leukotrienes and platelet-activating factor and the inflammatory response
  • hydrolyzes arachidonic acid from cellular membrane phospholipids, thereby providing enzymatic substrates for the synthesis of eicosanoids, such as prostaglandins and leukotrienes
  • catalyzes the first step in the arachidonic acid cascade leading to the synthesis of important lipid mediators, the prostaglandins and leukotrienes
  • PLA2G4A and EHD1 are involved in the vesiculation of CD59-containing endosomes
  • PLA2G4A/arachidonic acid signaling mediates depolarization-induced suppression of excitation in the cerebellum
  • modulates arachidonic acid production, thus tightly regulating the downstream effects of pro- and anti-inflammatory eicosanoids
  • important isoform of PLA2 that mediates the release of arachidonic acid
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HTATIP
  • interacting with KLF11 (silences PLA2G4A and down-regulates PGE2)
  • induces potentially membrane curvature and allows EHD1, possibly in the context of a complex, to sever the curved membranes into vesicles
  • its activity plays a crucial role in the signaling cascade leading to apoptotic neuronal death by aggregated APP probably via activation of N-SMase, ceramide production and caspases-3 and -8
  • osteoblastic cytosolic PLA2G4A is crucially involved in EDN1-induced prostaglandin formation
  • acts as a bridge in the formation of a multiprotein complex at the G2-to-M transition to promote binding of SIRT2 to CCNA2-CDK2
  • PLA2G4A -dependent pathways contribute to the novel regulatory role of hepatic ANXA6 in lipid droplet (LD) formation
  • cell & other
    REGULATION
    activated by the interaction between MAPK3/MAPK1 couple and KSR1
    increased intracellular Ca2+ levels and phosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s) PLA2G4AD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal adenocarcinoma
    constitutional     --over  
    in Alzheimer disease (AD) brain associated with amyloid deposits
    constitutional       loss of function
    attenuates not only lipid deposition in the liver but also hepatic fibrosis formation
    Susceptibility to schizophrenia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyacquired 
    attractive therapeutic target for ameliorating secondary tissue damage and promoting recovery of function after spinal cord injury
    ANIMAL & CELL MODELS