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FLASH GENE
Symbol ADORA2B contributors: mct/npt - updated : 09-03-2016
HGNC name adenosine A2b receptor
HGNC id 264
DNA
TYPE functioning gene
STRUCTURE 30.98 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1885 - 332 - Jacobson (1995)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivemouthtongue  highly
Respiratoryrespiratory tractlarynx   
Skin/Tegumentskin    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
not specificadipocyte Homo sapiensFetal
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text found both in the nucleus and the cytoplasm (Cui 2008)
    basic FUNCTION
  • adenosine receptor B2, activating adenylate cyclase
  • stimulating adenylate cyclase activity in the presence of adenosine
  • may have a significant role in the pathogenesis of the neurological manifestations of Lesch-Nyhan syndrome (Garcia 2009)
  • poor A2BR expression at the cell surface might be accounted for mainly by the lack of a dominant forward transport signal from the endoplasmic reticulum to the plasma membrane
  • ADORA1 and ADORA2B are both involved in differentiation to Treg, but through different mechanisms
  • is a new regulator of osteoblast differentiation, bone formation, and fracture repair
  • is a significant regulator of high cholesterol diet (HFD)-induced hallmarks of Type 2 Diabetes
  • is a regulator of adipocyte differentiation and the ADORA2B-KLF4 axis is a potentially significant modulator of adipose biology
  • ADORA2B signaling mediates different types of cardioprotection in a tissue-specific manner
  • following TLR stimulation, macrophages upregulate ADORA2B to enhance their sensitivity to immunosuppressive extracellular adenosine
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NTN1 receptor
  • ADORA2B adenosine receptor signaling protects during acute kidney injury via inhibition of neutrophil-dependent TNF release
  • interacting with Netrin 1, which is involved in axon elongation
  • HIF1A is transcriptional regulator of ADORA2B during acute lung injury
  • ADORA2B is essential for adenosine-induced SPHK1 activity in normal and sickle erythrocytes
  • ADORA2B signaling represses CIITA transcription in VSMCs by manipulating the interaction between STAT1 and the epigenetic machinery
  • cell & other
    REGULATION
    Other upregulated in melanocytes exposed to 4-tertiary butyl-phenol (4-TBP)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    activation of the ADORA2B on macrophages plays an active role in the pathogenesis of lung fibrosis and pulmonary hypertension
    constitutional     --over  
    associated with hyperglycemia in women with gestational diabetes mellitus
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularatheroma 
    use of ADORA2B agonists in the treatment or prevention of myocardial injury by ischemia
    diabetetype 2 
    therapeutic strategies targeting ADORA2B hold promise for preventing adipose tissue inflammation and insulin resistance
    cancermetastases 
    inhibiting ADORA2B may be an effective method to prevent metastasis
    ANIMAL & CELL MODELS