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FLASH GENE
Symbol MNDA contributors: mct - updated : 09-09-2019
HGNC name myeloid cell nuclear differentiation antigen
HGNC id 7183
DNA
TYPE functioning gene
STRUCTURE 18.00 kb     7 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1716 - 407 - 2015 25665578
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticgranulocyte
Blood/Hematopoieticleukocyte
Lymphoid/Immunemacrophage Homo sapiens
cell lineage myeloid cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one DAPIN domain
  • one HIN-200 domain
  • a pyrin domain that functions in signaling associated with programmed cell death and inflammation
  • HOMOLOGY
    interspecies homolog to murine Ifi201, Ifi202
    intraspecies homolog to IFI16
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    text nuclear in interphase, only in nuclei of cells of the granulocyte-monocyte lineage
    basic FUNCTION
  • participating in blood cell-specific responses to interferons
  • may be acting as a transcriptional activator/repressor in the myeloid lineage
  • MNDA and related proteins appear to modulate the activity of transcription factors and in some cases have a role in mediating cell death
  • has likely a role regulating programmed cell death in myeloid progenitor cells, and its down-regulation in myelodysplastic syndromes (MDS) is related to granulocyte-macrophage progenitor cell sensitivity to TNFSF10-induced programmed cell death
  • role of FGF4 and MNDA in pluripotent cell responses to genotoxicity
  • is a nuclear protein that labels myelomonocytic cells as well as B lymphocytes that localize to the marginal zone areas of splenic white pulp
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • FCRL4 and MNDA are useful markers in the differential diagnosis of marginal zone lymphomas (MZLs)
  • is useful in the differential diagnosis of marginal zone lymphomas with follicular lymphoma
  • Therapy target
    ANIMAL & CELL MODELS