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FLASH GENE
Symbol RFC5 contributors: mct - updated : 01-12-2010
HGNC name replication factor C (activator 1) 5, 36.5kDa
HGNC id 9973
DNA
TYPE functioning gene
STRUCTURE 25.02 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2485 36.1 319 - 1995 7774928
11 - 2121 38.5 340 - 1995 7774928
12 - 2180 36.1 319 - 1995 7774928
12 - 2247 - 255 - 1995 7774928
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PCNA binding region,
  • an ATP binding domain
  • a DEAD/H box (Asp-Glu-Ala-Asp/His)
  • mono polymer heteromer , pentamer
    HOMOLOGY
    interspecies homolog to murine Rfc5
    homolog to Drosophila rfc3
    homolog to C.elegans pqn-38
    Homologene
    FAMILY
  • activator 1 small subunits family
  • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • component of complex A-1, DNA polymerase accessory protein "clamp loader", ATP dependent,required to assemble PCNA and polymerase delta on the DNA template
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heteropentamer of subunits of 140/145, 40, 38, 37 and 36.5 kDa
  • complex ATAD5-RFC2-RFC5 functions in a fundamental DNA metabolism to suppress genomic instability
  • INTERACTION
    DNA binding
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • binding to PCNA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS