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FLASH GENE
Symbol GRIK5 contributors: mct - updated : 08-04-2019
HGNC name glutamate receptor, ionotropic, kainate 5
HGNC id 4583
DNA
TYPE functioning gene
STRUCTURE 73.49 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 3331 - 981 - 2013 23288040
18 - 3551 - 980 - 2013 23288040
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel     Homo sapiens
Lymphoid/Immunelymph node   highly
Nervousspinal cord   highly Mus musculusFetal
 spinal cordposterior horn    Mus musculusAdult
Reproductivemale systemtestis  highly
Respiratoryrespiratory tractlarynx  highly
Visualeyeretina  highly Mus musculusFetal
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell Homo sapiens
Visualcone photoreceptor Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four transmembrane segments (4TM)
  • ER-retention motif within the cytosolic domain
  • HOMOLOGY
    Homologene
    FAMILY glutamate-gated ionic channel family
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    text concentrated to a greater degree on postsynaptic membranes
    basic FUNCTION
  • glutamate receptor KA2, ionotropic, kainate (2-carboxy-4-(1-methenylethenyl)-3-pyrrolidinacetic) class
  • acting as an excitatory neurotransmitter at many synapses in the central nervous system
  • glutamate-binding receptor that has been implicated in the regulation of neurotransmission in the brain and sensory organs
  • likely linked to the patterning and maintenance of the vasculature
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component homomeric associations do not produce any channel activity
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with GRIK1 (both edited and unedited versions), GRIK2, or GRIK3 to form functional channels
  • interacting with GRIK2, GRIK1 AND KIF17
  • CAMK2A, CAMK2B-dependent phosphorylation of GRIK5 is responsible for synaptic depression by untrapping of kainate receptors (KARs) from the PSD and increased diffusion away from synaptic sites
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    of GRIK4, and GRIK5 in the hippocampus of patients with temporal lobe epilepsy (TLE)
    constitutional     --low  
    reduced genetically predicted expression of GRIK5 with comorbid vascular and eye diseases
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Grik5-deficient embryos fail to pattern blood vessels in the brain, and this failure results in fewer, smaller branches