SUBCELLULAR LOCALIZATION
| extracellular
|
| plasma membrane
|
| intracellular
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,cytosolic
|
| intracellular,nucleus,nucleoplasm
|
basic FUNCTION
| receptor for membrane-bound ligands Jagged1, Jagged2, Delta-like1, Delta-like3 and Delta-like4 |
|
an important element in dental physiological and pathogenic conditions ( |
|
mediating cell-cell interactions that specify cell fate during development |
|
as other Notch family members and ligands, expressed in the human corneal epithelium and appear to play pivotal roles in corneal epithelial cell differentiation |
|
central regulator of pancreatic intraepithelial neoplasia progression and malignant transformation |
|
essential role of NOTCH2 and MYC in the initiation of a neoplastic transformation program in pancreatic cells |
|
play a role in the regulation of red cell differentiation ( |
|
important role for NOTCH2 signaling in bone homeostasis |
|
importance of NOTCH2 in the development and maintenance of the skeleton, and modulate RANKL-induced osteoclastogenesis |
|
NOTCH2 and NOTCH3 act together to govern vascular development and smooth muscle differentiation |
|
Notch signaling through the NOTCH2 receptor is essential for normal biliary tubulogenesis during liver development |
|
NOTCH1 and NOTCH2 expression in osteoblast precursors regulates cancellous bone volume and microarchitecture |
|
canonical, NOTCH2-dependent signaling plays likely a role in human decidualization |
|
NOTCH2 signalling, activated by cell-cell contact of neighbouring distal cell column trophoblasts (dCCTs), could attenuate trophoblast migration |
|
NOTCH1 is the primary receptor regulating intestinal stem cell function and NOTCH1 and NOTCH2 together regulate epithelial cell proliferation, cell fate determination, and post-injury regeneration |
|
discrete roles for NOTCH2 and NOTCH3 in VSMCs and these roles are linked to specific upstream regulators that control their expression |
|
NOTCH2 and NOTCH3 have overlapping roles in promoting development of vascular smooth muscle cells, and together contribute to functional closure of the ductus arteriosus |
|
NOTCH2 and NOTCH3 inhibited both cell proliferation and cell apoptosis trophoblast cell lines |
|
NOTCH1 and NOTCH2 are the primary NOTCH receptors regulating epithelial cell homoeostasis in human stomach |
|
physiologically regulates bone remodeling by inhibiting trabecular bone formation in the appendicular skeleton |
|
NOTCH2 signaling is linked to MYC expression and plays a key role in the regulation of Mesenchymal stem/stromal cells (MSCs) proliferation |