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FLASH GENE
Symbol COIL contributors: mct - updated : 12-03-2011
HGNC name coilin
HGNC id 2184
DNA
TYPE functioning gene
STRUCTURE 22.85 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2649 - 576 - 2010 20875822
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Reproductivefemale systemuteruscervix highly
 male systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminus is responsible for self-association leading to the characteristic fibrous pattern observed in Cajal bodies
  • two nuclear localization signal sequences (NLS)
  • a region rich in arginine and glycine (RG-box)
  • C-terminal region contains a Tudor domain, atypical due to the presence of several unstructured loops, one greater than thirty AAs in length
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,coiled bodies (Cajal)
    intracellular,nucleus,nucleolus
    text protein of the non-capsular nuclear bodies (coiled bodies), in interphase cells
    basic FUNCTION
  • with SMN have several putative motifs of SUMO-1 modification, suggesting that the sumoylation of COIL and/or SMN might play a role in the molecular reorganization of Cajal bodies during the neuronal differentiation or stress-response
  • integral component of Cajal bodies (also called coiled bodies), nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs
  • plays a role in Cajal body formation
  • nucleoplasmic coilin participates in the regulation of DNA repair
  • nuclear phosphoprotein that concentrates within Cajal bodies (CBs) and impacts snRNP (small nuclear ribonucleoprotein) biogenesis
  • having a function, independent of its role in snRNP biogenesis, establishing a new link between the DNA damage response (DDR) and the inhibition of rRNA synthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • one of the most critical components of the Cajal body
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ATXN1 (implicated in altering the function of ataxin-1)
  • interacts with XRCC5 and XRCC6, which are major players in the DNA repair process
  • cell & other
    REGULATION
    Phosphorylated by in Ser184 by both VRK1 and VRK2 (COIL colocalizes and interacts with VRK1 in Cajal bodies, but not with the mutant VRK1)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS