basic FUNCTION
| with SMN have several putative motifs of SUMO-1 modification, suggesting that the sumoylation of COIL and/or SMN might play a role in the molecular reorganization of Cajal bodies during the neuronal differentiation or stress-response |
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integral component of Cajal bodies (also called coiled bodies), nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs |
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plays a role in Cajal body formation |
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nucleoplasmic coilin participates in the regulation of DNA repair |
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nuclear phosphoprotein that concentrates within Cajal bodies (CBs) and impacts snRNP (small nuclear ribonucleoprotein) biogenesis |
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having a function, independent of its role in snRNP biogenesis, establishing a new link between the DNA damage response (DDR) and the inhibition of rRNA synthesis |