basic FUNCTION
| hydrolyzing GTP of the 40S ribosomal initiation complex |
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plays multiple roles in translation initiation |
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stabilizes the binding of GDP to EIF2 and is therefore a bi-functional protein that acts as a GDP dissociation inhibitor (GDI) |
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multifunctional protein with separate GDI (GDP dissociation inhibitor) and GAP (GTPase accelerating protein) activities, both necessary for controlled translation initiation in eukaryotes |
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C-terminal domain (CTD) of EIF5 stimulates 43S preinitiation complex (PIC) assembly |
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plays an important role in translation start site selection by providing the GAP (GTPase activating protein) function |
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levels of eukaryotic translation initiation factors 1 (EIF1) and 5 (EIF5) play critical roles in controlling the stringency of translation start site selection |
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key role of EIF5 in start-codon selection |