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FLASH GENE
Symbol FCGR2C contributors: mct - updated : 13-02-2013
HGNC name Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
HGNC id 15626
DNA
TYPE like-sequence
STRUCTURE 18.90 kb     7 Exon(s)
motif repetitive sequence   other
text structure
  • only FCGR3A, FCGR2C and FCGR3B show CNV
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1510 35 323 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Blood/Hematopoieticplatelet
    Endocrineislet cell (alpha,beta...)
    Lymphoid/ImmuneB cell Homo sapiensAdult
    Lymphoid/Immunemacrophage
    Lymphoid/Immunenatural killer Homo sapiensAdult
    cell lineage primarily, by cells of the myeloid lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two Ig extracellular domains
  • a cytoplasmic tail with the immunoreceptor tyrosine based inhibitory motifs (ITIM)
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B cells
  • glycoprotein that bind the Fc region of IgG
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to idiopathic thrombocytopenic purpura (ITP)
    Variant & Polymorphism other
  • activating FCGR2C-ORF genotype predisposes to ITP by altering the balance of activating and inhibitory FCGR on immune cells
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS