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FLASH GENE
Symbol KCNMA1 contributors: mct/npt - updated : 23-06-2014
HGNC name potassium large conductance calcium-activated channel, subfamily M, alpha member 1
HGNC id 6284
DNA
TYPE functioning gene
STRUCTURE 768.22 kb     29 Exon(s)
10 Kb 5' upstream gene genomic sequence study
motif
text structure no TATA box
MAPPING cloned Y linked N status confirmed
Map cen - D10S195 - D10S580 -D10S1730 - KCNMA1 - D10S605 - D10S1752 - D10S206 - SFTPD - ANXA11 - D10S1786 - qter
RNA
TRANSCRIPTS type messenger
text multiple transcripts by alternative splicing (PMID: 7987297)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
27 - 6120 - 1178 - 2008 18227273
28 splicing 6294 - 1236 overexpressed in glioma cells -
63 AA insert at splice site 2
28 splicing 6243 - 1219 - -
29 AA insert at splice site 2; having the greatest calcium sensitivity
29 - 11994 - 1182 - 2008 18227273
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselsaorta   
Reproductivefemale systemuterus  highly
Respiratorynasopharynx   highly
 respiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
IMPRINTING maternally
text down-regulated expression in androgenetic placentas
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • N-terminal seven transmembrane domains (S0 to S6)
  • two functional domains, a core consisting of four voltage sensors controlling an ion-conducting pore, and a larger tail that forms an intracellular gating ring thought to confer Ca(2+) and Mg(2+) sensitivity
  • a RCK1 domain between S6 and S8, that is a high-affinity Ca(2+) sensor that transduces Ca(2+) binding into structural rearrangements, likely representing elementary steps in the Ca(2+)-dependent activation of KCNMA1 channels
  • a calcium bowl
  • CRAC motifs, cholesterol-binding motifs
  • an extensive C-terminus with four hydrophobic segments (S7 to S10), and a motif required for surface targeting
  • mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to Drosophila slowpoke
    Homologene
    FAMILY
  • potassium channel family
  • calcium-activated subfamily
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • control of smooth muscle tone and neuronal excitability
  • constituting the calcium-activated potassium channel and playing a key role in controlling excitability in a number of systems, such as regulation of the contraction
  • of smooth muscle, the tuning of hair cells in the cochlea,
    regulation of transmitter release, and innate immunity
  • play a fundamental role in cellular function by integrating information from their voltage and Ca(2+) sensors to control membrane potential and Ca(2+) homeostasis
  • role of endothelial KCNM1A channels in altered vasoreactivity following hypoxia
  • mediate cholinergic inhibition of high frequency cochlear hair cells
  • play important roles in regulating vascular contractility
  • (egulate neuronal functions such as spike frequency adaptation and transmitter release
  • modulate visual responses in vivo at the bipolar cell level at intermediate stimulus conditions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission , signal transduction
    a component
  • pore constituent (forming alpha member 1) complexing with alternative beta subunits
  • composed of four KCNMA1 subunits, which contain the voltage-sensing and pore-gate domains in the membrane and Ca(2+) binding sites in the cytoplasmic domain, and accessory beta subunits
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4
  • interaction with caveolin-1 (interaction facilitating the tethering of the KCNMA1 C-terminal end to the membrane)
  • binds MAGI1
  • WNK4 inhibits KCNMA1 activity by reducing KCNMA1 protein at the membrane, but the inhibition is not due to an increase in clathrin-mediated endocytosis of KCNMA1, but likely due to enhancing its lysosomal degradation
  • insulin stimulation of KCNMA1 channels in podocytes may prepare podocytes to adapt to changes in pressure gradients that occur during postprandial hyperfiltration
  • RAB11B has a moderate association with a region of KCNMA1 that includes AA 127616, and this interaction of RAB11B and KCNMA1 is in cochlea
  • lack of TMPRSS3 leads to a decrease in KCNMA1 potassium channels expression in inner hair cells (IHCs)
  • CRBN inactivation releases deubiquitinated KCNMA1 channels from the ER to the plasma membrane, leading to markedly enhanced channel activity
  • LRRC26 associates with KCNMA1 subunits, and elevates channel voltage- and apparent Ca2+-sensitivity in arterial myocytes to induce vasodilation (PMID;
  • cell & other
    REGULATION
    activated by intracellular Zn(2+) that potently and reversibly activates large-conductance voltage- and Ca(2+)-activated KCNMA1
    ASSOCIATED DISORDERS
    corresponding disease(s) GEPD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in late-stage prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target promising diagnostic and therapeutic target in patients with prostate cancer
    ANIMAL & CELL MODELS