proximal promoter of the Cdc2L2 gene GC rich and not containing TATA and CAAT boxes
multiple consensus and near consensus transcription factor binding sites, such as two Ets-1, one cAMP-responsive element (CRE) and one TCF11/LCR-F1/Nrf1 binding sites
MAPPING
cloned
Y
linked
N
status
confirmed
RNA
TRANSCRIPTS
type
messenger
identification
nb exons
type
bp
product
Protein
kDa
AA
specific expression
Year
Pubmed
-
splicing
2448
-
780
-
1994
8195233
also called variant 5/isoform 5
same isoform than variant 8
-
splicing
2436
90.7
776
-
1994
8195233
also called variant 3/isoform 3
20
splicing
2620
-
770
-
2007
17606997
also called ariant 4/isoform 4
20
splicing
2650
110
780
expressed at constant levels during the cell cycle
2007
17606997
also called variant 1 or p110
contains an IRES (internal ribosome entry site) that allows the expression of a smaller p58(PITSLRE) isoform during the G2/M stage of the cell cycle
involved in transcription and RNA processing
-
splicing
2471
90.7
777
-
1994
8195233
also called variant 8/isoform 8
same isoform than variant 1
-
splicing
2465
90.7
775
-
1994
8195233
also called variant 9/isoform 9
-
splicing
1767
58
439
expressed only during G2 and M phases
2006
16462731
also called p58, variant 10/isoform 10
specifically translated from an internal ribosome entry site sequence during G2/M
involved in centrosome maturation and spindle morphogenesis (Hu 2007)
also required for sister chromatid cohesion and the completion of mitosis (Hu 2007)
role in centrosome maturation and bipolar spindle morphogenesis.
a G2/M specific protein that contributed to regulation of cell cycle, transcription and apoptotic signal transduction
exert important functions in mitotic process, such as the regulation of bipolar spindle formation and sister chromatid cohesion
role of CCND3/CDK11A complex in repressing the Schwann cells proliferation and inducing its apoptosis
CELLULAR PROCESS
cell cycle
cell life, cell death/apoptosis
PHYSIOLOGICAL PROCESS
text
cell cycle control
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
nucleotide,
ATP
protein
interacting with PAK1(PAK1 may serve as a downstream effector of CDC2L2 during mitosis progression)
interacting with ESR1 (ESR1 was down-regulated by CDC2L2 in mammalian cells in a ligand independent manner)
CDK11A that is broadly distributed onto chromatin and phosphorylates the MED27 and MED4 Mediator subunits on conserved residues
CHEK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11A(p110)
CDK11A is an anti-metastatic gene in ESR1-positive breast cancer and that the regulation of ITGB3 by CDK11 via the repression of ESR1 signaling may constitute part of a signaling pathway underlying breast cancer invasion
involved in G2/M transition and degradation of several transcription factors, CDK11A directly interacts with and phosphorylates SPDEF on serine residues, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
Type
Gene Modification
Chromosome rearrangement
Protein expression
Protein Function
tumoral
 
deletion
 
 
in neuroblastoma
constitutional
 
 
--low
 
caused defective chromosome congression, premature sister chromatid separation, permanent mitotic arrest and cell death
Susceptibility
to type 2 diabetes in a Han Chinese cohort
Variant & Polymorphism
SNP
SNP11 strongly associated with female patients with T2D