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FLASH GENE

Symbol

CDK11A

contributors: mct/pgu - updated : 27-06-2016

HGNC name	cyclin-dependent kinase 11A
HGNC id	1730

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	opposite orientation, tail to tail
text	close to CDC2L1
STRUCTURE	21.62 kb     20 Exon(s)

regulatory sequence	Promoter
	Binding site
text structure	proximal promoter of the Cdc2L2 gene GC rich and not containing TATA and CAAT boxes
	multiple consensus and near consensus transcription factor binding sites, such as two Ets-1, one cAMP-responsive element (CRE) and one TCF11/LCR-F1/Nrf1 binding sites

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_033531 - splicing 2448 NP_277073 - 780 - 1994 8195233 also called variant 5/isoform 5 same isoform than variant 8 NM_033528 - splicing 2436 NP_277070 90.7 776 - 1994 8195233 also called variant 3/isoform 3 NM_033529 20 splicing 2620 NP_277071 - 770 - 2007 17606997 also called ariant 4/isoform 4 NM_024011 20 splicing 2650 NP_076916 110 780 expressed at constant levels during the cell cycle 2007 17606997 also called variant 1 or p110 contains an IRES (internal ribosome entry site) that allows the expression of a smaller p58(PITSLRE) isoform during the G2/M stage of the cell cycle involved in transcription and RNA processing NM_033536 - splicing 2471 NP_284922 90.7 777 - 1994 8195233 also called variant 8/isoform 8 same isoform than variant 1 NM_033537 - splicing 2465 NP_284923 90.7 775 - 1994 8195233 also called variant 9/isoform 9 NM_033621 - splicing 1767 NP_296370 58 439 expressed only during G2 and M phases 2006 16462731 also called p58, variant 10/isoform 10 specifically translated from an internal ribosome entry site sequence during G2/M involved in centrosome maturation and spindle morphogenesis (Hu 2007) also required for sister chromatid cohesion and the completion of mitosis (Hu 2007) role in centrosome maturation and bipolar spindle morphogenesis.

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive intestine large intestine colon   highly Hearing/Equilibrium ear       highly Lymphoid/Immune lymph node       highly Reproductive female system ovary     highly Respiratory lung         Visual eye       highly

cell lineage

cell lines

fluid/secretion

at STAGE

life cycle

division

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a helicase ATP-binding domain
	a helicase c-terminal domain

HOMOLOGY

interspecies	homolog to Drosophila Pitslre
	homolog to C.elegans B0495.2

Homologene

FAMILY	protein kinase superfamily
	CMGC Ser/Thr protein kinase family
	CDC2/CDKX subfamily

CATEGORY

enzyme , receptor serine/threonine kinase

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	playing roles in cell apoptosis
	a G2/M specific protein that contributed to regulation of cell cycle, transcription and apoptotic signal transduction
	exert important functions in mitotic process, such as the regulation of bipolar spindle formation and sister chromatid cohesion
	role of CCND3/CDK11A complex in repressing the Schwann cells proliferation and inducing its apoptosis

CELLULAR PROCESS	cell cycle
	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

text	cell cycle control

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein	interacting with PAK1(PAK1 may serve as a downstream effector of CDC2L2 during mitosis progression)
	interacting with ESR1 (ESR1 was down-regulated by CDC2L2 in mammalian cells in a ligand independent manner)
	CDK11A that is broadly distributed onto chromatin and phosphorylates the MED27 and MED4 Mediator subunits on conserved residues
	CHEK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11A(p110)
	CDK11A is an anti-metastatic gene in ESR1-positive breast cancer and that the regulation of ITGB3 by CDK11 via the repression of ESR1 signaling may constitute part of a signaling pathway underlying breast cancer invasion
	involved in G2/M transition and degradation of several transcription factors, CDK11A directly interacts with and phosphorylates SPDEF on serine residues, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in neuroblastoma constitutional     --low   caused defective chromosome congression, premature sister chromatid separation, permanent mitotic arrest and cell death

Susceptibility

to type 2 diabetes in a Han Chinese cohort

Variant & Polymorphism SNP	SNP11 strongly associated with female patients with T2D

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS