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FLASH GENE
Symbol CDK11A contributors: mct/pgu - updated : 27-06-2016
HGNC name cyclin-dependent kinase 11A
HGNC id 1730
DNA
TYPE functioning gene
SPECIAL FEATURE opposite orientation, tail to tail
text close to CDC2L1
STRUCTURE 21.62 kb     20 Exon(s)
regulatory sequence Promoter
Binding site
text structure
  • proximal promoter of the Cdc2L2 gene GC rich and not containing TATA and CAAT boxes
  • multiple consensus and near consensus transcription factor binding sites, such as two Ets-1, one cAMP-responsive element (CRE) and one TCF11/LCR-F1/Nrf1 binding sites
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2448 - 780 - 1994 8195233
  • also called variant 5/isoform 5
  • same isoform than variant 8
  • - splicing 2436 90.7 776 - 1994 8195233
    also called variant 3/isoform 3
    20 splicing 2620 - 770 - 2007 17606997
    also called ariant 4/isoform 4
    20 splicing 2650 110 780 expressed at constant levels during the cell cycle 2007 17606997
  • also called variant 1 or p110
  • contains an IRES (internal ribosome entry site) that allows the expression of a smaller p58(PITSLRE) isoform during the G2/M stage of the cell cycle
  • involved in transcription and RNA processing
  • - splicing 2471 90.7 777 - 1994 8195233
  • also called variant 8/isoform 8
  • same isoform than variant 1
  • - splicing 2465 90.7 775 - 1994 8195233
    also called variant 9/isoform 9
    - splicing 1767 58 439 expressed only during G2 and M phases 2006 16462731
  • also called p58, variant 10/isoform 10
  • specifically translated from an internal ribosome entry site sequence during G2/M
  • involved in centrosome maturation and spindle morphogenesis (Hu 2007)
  • also required for sister chromatid cohesion and the completion of mitosis (Hu 2007)
  • role in centrosome maturation and bipolar spindle morphogenesis.
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon highly
    Hearing/Equilibriumear   highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemovary  highly
    Respiratorylung    
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    life cycle division
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a helicase ATP-binding domain
  • a helicase c-terminal domain
  • HOMOLOGY
    interspecies homolog to Drosophila Pitslre
    homolog to C.elegans B0495.2
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • CDC2/CDKX subfamily
  • CATEGORY enzyme , receptor serine/threonine kinase
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing roles in cell apoptosis
  • a G2/M specific protein that contributed to regulation of cell cycle, transcription and apoptotic signal transduction
  • exert important functions in mitotic process, such as the regulation of bipolar spindle formation and sister chromatid cohesion
  • role of CCND3/CDK11A complex in repressing the Schwann cells proliferation and inducing its apoptosis
  • CELLULAR PROCESS cell cycle
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text cell cycle control
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting with PAK1(PAK1 may serve as a downstream effector of CDC2L2 during mitosis progression)
  • interacting with ESR1 (ESR1 was down-regulated by CDC2L2 in mammalian cells in a ligand independent manner)
  • CHEK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11A(p110)
  • CDK11A is an anti-metastatic gene in ESR1-positive breast cancer and that the regulation of ITGB3 by CDK11 via the repression of ESR1 signaling may constitute part of a signaling pathway underlying breast cancer invasion
  • involved in G2/M transition and degradation of several transcription factors, CDK11A directly interacts with and phosphorylates SPDEF on serine residues, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in neuroblastoma
    constitutional     --low  
    caused defective chromosome congression, premature sister chromatid separation, permanent mitotic arrest and cell death
    Susceptibility to type 2 diabetes in a Han Chinese cohort
    Variant & Polymorphism SNP SNP11 strongly associated with female patients with T2D
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS