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FLASH GENE
Symbol CNTN1 contributors: mct/npt - updated : 25-10-2016
HGNC name contactin 1
HGNC id 2171
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 379.97 kb     23 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D12S1931 - D12S1474 - D12S2001 - (D12S1029 ,D12S1067 ) - D12S331 - D12S1928 - D12S3067 - D12S1930 - D12S1470 - D12S1243E - D12S1469 - D12S1269 - D12S1048 - D12S1668 - D12S1065 - (CNTN1 ,D12S315 ,D12S247 ) - D12S1271 - D12S1081 - D12S1296 - D12S1090 - D12S1130E - (D12S1424 ,D12S1589 ,D12S1592 ,D12S1198E ) - (D12S856 ,D12S1653 ) - D12S1473 - D12S29 - D12S1080 - qter
Authors 4st Workshop chrom.12 (97)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 6600 32 974 - 2016 26721881
- - - - 963 brain 2016 26721881
shorter N terminus
24 - 5664 - 1018 - 2016 26721881
23 - 5480 - 1007 - 2016 26721881
16 - 3315 - 627 - 2016 26721881
16 - 3528 - 627 - 2016 26721881
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
Nervousoligodendrocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six C2 Ig-like domains
  • four FNIII-like extracellular domains
  • a single transmembrane segment (TM)
  • a GPI anchor Ig-like and FNIII domains, wuth Ig repeats 2 and 3 that interact with the CA-like domain found at the N terminus of the PTPRZ1 extracellular domain
  • a short cytoplasmic tail
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • contactin family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text expressed at the neuromuscular junction
    basic FUNCTION
  • neuronal cell adhesion molecule, involved in axon growth and initiating a NOTCH/DTX1 signaling pathway that promotes oligodendrocyte maturation and myelination
  • may play a role in the formation of axon connections in the developing nervous system
  • playing a role at the neuromuscular junction
  • playing a role in the regulation of neurite growth, synapse formation, fasciculation, and myelin organization
  • CNTN1, CNTN2 and L1-like proteins (NRCAM) play a significant role in modulating SHH-induced neuronal precursor proliferation
  • plays a general role in neural development and, in particular, in neuronal and oligodendrocyte differentiation
  • reduces CDH1 expression via activating AKT1 in lung cancer
  • is involved in several aspects of neural development including synapse building, maintenance and functioning
  • plays likely a role in promoting adult hippocampal neurogenesis and this effect correlates with improved synaptic function and memory
  • regulates both myelin formation and organization of nodal and paranodal domains in the CNS
  • neural cell adhesion protein, hat is a prostate cancer-promoting factor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component PTPRZ1/CNTN1 complex is a previously unknown modulator of oligodendrogenesis
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NOTCH1 and NOTCH2 ligand
  • interacting with PTPRZ2 (Abdelhakim 2010)
  • PTPRZ1 binds specifically to CNTN1 expressed at the surface of oligodendrocyte precursor cells
  • enhances AKT1 activation in part by preventing PHLPP2-mediated AKT1 dephosphrorylation
  • PTPRA interacts with CNTN1 to form a membrane-spanning co-receptor complex to transduce extracellular signals to FYN tyrosine kinase
  • cell & other
    REGULATION
    Other regulated by CNTNAP1 (regulates the intracellular processing and transport of contactin to the cell surface, thereby affecting its ability to interact with other cell adhesion molecules)
    ASSOCIATED DISORDERS
    corresponding disease(s) FLCM
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in glioblastomas compared with normal brain
    tumoral     --over  
    in gastric cancer tissues compared with adjacent normal tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be a novel biomarker of the cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    possible therapeutic target in cancer treatment in the near future
    cancerdigestivestomach
    may be a potential therapeutic target for gastric cancer
    ANIMAL & CELL MODELS