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FLASH GENE
Symbol OGDHL contributors: mct - updated : 04-01-2022
HGNC name oxoglutarate dehydrogenase-like
HGNC id 25590
DNA
TYPE functioning gene
STRUCTURE 27.74 kb     23 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 3330 - 801 - 2021 34800363
22 - 3535 - 953 - 2021 34800363
23 - 3706 114.5 1010 - 2021 34800363
21 - 3292 - 801 - 2021 34800363
22 - 3497 - 953 - 2021 34800363
20 - 3397 - 611 - 2021 34800363
22 - 3488 - 950 - 2021 34800363
22 - 3837 - 741 - 2021 34800363
22 - 3526 - 950 - 2021 34800363
23 - 4017 - 801 - 2021 34800363
23 - 3652 - 1010 - 2021 34800363
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain     Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to Drosophila CG11661
homolog to C.elegans T22B11.5
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
intracellular,cytoplasm,organelle,mitochondria,matrix
text mitochondrial localization
basic FUNCTION
  • converting alpha-ketoglutarate to succinyl coenzyme A in the Krebs cycle
  • may thus participate in brain-specific control of 2-oxoglutarate distribution between energy production and synthesis of the neurotransmitter glutamate
  • is an important anti-proliferative gene in cervical cancer
  • OGDH and OGDHL play an essential part in a rate-limiting enzymatic reaction for the conversion of alpha-ketoglutarate (alpha-KG) to succinyl-CoA
  • potential involvement of OGDHL in brain development and function
  • both OGDHL and OGDH are required for mitochondrial metabolism in human neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid , carbohydrate , organic acid
    signaling
    Krebs cycle
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NDDEDV
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    contributed to hepatocellular carcinoma (HCC) development and survival by regulating glutamine metabolic pathways
    tumoral       loss of function
    can contribute to cervical tumorigenesis via activation of the AKT1 signaling pathway
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a promising prognostic biomarker for HCC
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    therapeutic target for HCC
    neurologyneurodegenerativealzheimer
    may be a potential strategy for AD treatment
    ANIMAL & CELL MODELS