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FLASH GENE
Symbol CHRNA7 contributors: mct/npt/shn/pgu - updated : 23-01-2018
HGNC name cholinergic receptor, nicotinic, alpha 7 (neuronal)
HGNC id 1960
DNA
TYPE functioning gene
SPECIAL FEATURE
text partially duplicated
STRUCTURE 139.70 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D15S1013 - D15S1031 - CHRNA7 - D15S1010 - D15S231 - qter
RNA
TRANSCRIPTS type messenger
text transcription of CHRNA7 is modulated by chromatin interactions with the PWS-IC (PMID:21840925)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 splicing 2171 - 512 - 2017 29129316
10 splicing 3443 - 531 - 2017 29129316
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly Homo sapiensAdult
 brainlimbic systemhippocampusdentate gyrus  Homo sapiens
 brainlimbic systemhippocampus highly Homo sapiens
Visualeyeretina    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Nervouscentral  predominantly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunedendritic cell Homo sapiens
Lymphoid/Immunelymphocyte Homo sapiens
Lymphoid/Immunemacrophage Homo sapiens
Nervousneuron Homo sapiens
cell lineage
cell lines human neuroblastoma cell line SH-SY5Y and/or IMR-32 (
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a large N terminal extracellular domain
  • two agonist binding sites
  • four transmembrane segments (4TM) with the M2 domain comprising the cation-selective pore
  • conjugated Other
    mono polymer homomer , pentamer
    HOMOLOGY
    interspecies ortholog to chrna7, Danio rerio
    ortholog to Chrna7, Mus musculus
    ortholog to CHRNA7, Pan troglodytes
    ortholog to Chrna7, Rattus norvegicus
    Homologene
    FAMILY
  • ligand-gated ionic channel family
  • CATEGORY receptor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    text present in the outer membranes of mitochondria to regulate the early apoptotic events like cytochrome c release
    basic FUNCTION
  • regulating keratinocyte chemokinesis and chemotaxis, respectively, and signaling pathways mediating these functions, having clinical implications for wound healing and control of cancer metastases
  • implicated in neuronal functions, including learning, memory, and attention
  • plays an important role in non-small cell lung cancer cell growth and tumour progression as well as in cell death
  • plays a dominant role in nicotine-induced cell signaling
  • distinct and varied spatiotemporal expression of CHRNA7 during tooth development
  • is an important mediator of cholinergic transmission during brain development
  • exhibits a pleiotropic role in the hematopoietic system that includes both the direct modulation of pro-inflammatory cell composition and later in the adult the role of modulating pro-inflammatory responses that would impact upon an individual lifelong response to inflammation and infection
  • regulates axon growth in hippocampal neurons, thereby likely contributing to synaptic formation in the developing brain
  • regulate mitochondrial permeability transition pore formation through ion-independent mechanism involving activation of intramitochondrial PI3K/AKT1 pathway and inhibition of calcium-calmodulin-dependent or SRC-kinase-dependent signaling pathways
  • is a ligand-activated ion channel that contributes to a diversity of cellular processes involved in development, neurotransmission and inflammation
  • contributes to multiple aspects of adrenal gland development and function that persist into adulthood
  • role of the CHRNA7 in schizophrenia and likely cholinergic neurotransmission involving the CHRNA7 could be involved in sensory registration processes
  • activating CHRNA7 can promote diabetic wound healing by suppressing advanced glycation end products (AGEs)-induced TNF production, which may be closely associated with the blockage of NFKB1 activation in macrophages
  • make a complex contribution to network activity and synaptic plasticity in the prelimbic cortex
  • is emerging as an important drug target for intervention in inflammation and sepsis
  • anti-inflammatory role of CHRNA in Natural killer (NK) cells
  • has many important consequences in neuronal cells, including modulation of neuronal excitability and neurotransmitter release as well as calcium flux directly impacting multiple cellular signaling pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • 42-amino acid beta-amyloid peptide, Abeta(1-42) (
  • PI3K p85 subunit and Fyn (
  • PWS-IC (
  • TFAP2A plays a negative role in regulating CHRNA7 transcription
  • interaction between CHRNA7 and a G-protein pathway complex regulates neurite growth in neural cells
  • regulate the early apoptotic events like cytochrome c release
  • APP promotes translocation of CHRNA7 towards the cell surface and CHRNA7 rescues neuronal cells from APP-induced damage
  • RIC3 is a known chaperone of neuronal CHRNA7
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL15Q13 , DUP15Q13
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    may signal a compensatory response to maintain basocortical cholinergic activity during Alzheimer disease progression
    tumoral     --over  
    its expression is significantly higher in small-cell lung carcinoma (SCLC), as in carcinoid tumor
    Susceptibility to autism spectrum disorder
    Variant & Polymorphism other rare variants in autism spectrum disorder susceptibility
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    psychiatryschizophrenia 
    repression of CHRNA7 mRNA by TFAP2A might be evaluated as a potential modulatory factor in the development of pharmacological targets to treat the symptoms of schizophrenia and other mood disorders
    reproductiongenital 
    activation of CHRNA7 might be a new candidate for treatment of endometriosis
    neurologyneurodegenerativealzheimer
    activation of the CHRNA7/PI3K signaling pathway and its cross-talk with the Wnt signaling pathway might well be therapeutic targets for potential AD treatments
    ANIMAL & CELL MODELS
  • expression of CHRNA7 is significantly reduced frontal cortex from Rett syndrome and autism patients (
  • alpha7 nAChR knockout (KO) mouse is viable and has only slight visual dysfunction