| basic FUNCTION
| playing a role in elimination of peroxides generated during metabolism |
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having a function in apoptosis signal-regulating kinase 1 (MAP3K5)-mediated signaling pathway |
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have a role in both the resistance of certain cancers to therapy and quite a different role in possibly slowing the progression of neurodegenerative |
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having a function in apoptosis signal-regulating kinase 1 (MAP3K5)-mediated signaling pathway |
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peroxidase function of PRDX1 is involved in regulating RAS-induced transformation |
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pivotal regulator of GDPD5 activity, suggesting roles for coupled thiol-redox-dependent cascades in controlling neuronal differentiation in the spinal cord  |
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catalyze peroxide reduction of H(2)O(2), organic hydroperoxides and peroxynitrite |
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involved in the cellular protection against oxidative stress, the modulation of intracellular signalling cascades as well as the regulation of cell proliferation and apoptosis |
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essential for preventing respiratory syncytial virus-induced oxidative damage in a subset of nuclear intermediate filament and actin binding proteins in epithelial cells |
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PRDX1-stimulated endothelial cell proliferation, migration, and differentiation in a TLR4- and VEGF-dependent manner |
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role in regulating TGFB1-induced epithelial-to-mesenchymal transition (EMT) |
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detoxifies peroxide substrates and has been implicated in numerous biological processes, including cell growth, proliferation, differentiation, apoptosis, and redox signaling |
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may perform biological functions as a RNA-binding protein, which are distinctive from known functions of PRDX1 as a reactive oxygen species scavenger |
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novel role of PRDX1 in phagocytosis of macrophage |
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orchestrates potentially redox signaling in an H& |
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8322;O& |
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8322; dose-dependent manner through the oxidation status of its peroxidatic cysteine Cys52 |
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is involved in disassembly of flagella and cilia, and suggested that the abnormal expression of the cilia-related gene including PRDX1 may affect both ciliogenesis and cancerogenesis |
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site-specific acetylation of PRDX1 may change its biological role in response to environmental changes |
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involved in the control of the pericentrosomal H2O2 level that is critical for mitotic progression |
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interaction of PRDX1 with APEX1 represents a novel anti-inflammatory function of PRDX1, whereby the association safeguards APEX1 from reducing transcription factors and activating superfluous gene expression, which otherwise could trigger cancer invasion and metastasis |
