SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,cytoskeleton,microtubule
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| intracellular,cytoplasm,cytoskeleton,intermed filament
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,chromatin/chromosome,kinetochore
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text
| at the onset of mitosis, localizes to kinetochores, but at metaphase, it is no longer detectable at kinetochores |
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binds to microtubules in an N-terminal domain-dependent manner and this interaction is regulated by both conformational changes |
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CLIP1 colocalizes with Polo-like kinase 1 (PLK1) at kinetochores during early mitosis |
basic FUNCTION
| associated specifically with the ends of growing microtubules and may act as anti-catastrophe factors |
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plays pivotal roles in orientation of microtubules |
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regulates microtubule dynamics and has been implicated in cargo-microtubule interactions |
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microtubule 'plus end tracking' protein involved in several microtubule-dependent processes in interphase |
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facilitates the formation of kinetochore-microtubule attachments, possibly through direct capture of microtubules at the kinetochore |
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implicated in the formation of kinetochore–microtubule attachments through direct interaction with the dynein/dynactin complex |
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MAPRE1, MAPRE2 and CLIP1 are two well-studied microtubule plus-end-tracking proteins (+TIPs) that target growing microtubule plus ends in the form of comet tails and regulate microtubule dynamics |
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MAPRE2 and CLIP1 cooperatively regulate microtubule dynamic instability at concentrations below which neither protein is effective |
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outer kinetochore protein, having a role in kinetochore-microtubule attachment and chromosome alignment during mitosis |
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acts as a novel recruiter and spatial regulator of PLK1 at kinetochores during early mitosis, promoting K-fiber stability and chromosome alignment for error-free chromosome segregation |