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FLASH GENE
Symbol KCNMB4 contributors: npt/ - updated : 09-05-2005
HGNC name potassium large conductance calcium-activated channel, subfamily M, beta member 4
HGNC id 6289
DNA
TYPE functioning gene
STRUCTURE 64.92 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1631 23.82 210 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   moderately
Reproductivemale systemprostate  moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two conserved transmembranes domains
  • an extracellular domain
  • an N glycosylation site
  • four cys residues
  • mono polymer aggregate
    HOMOLOGY
    interspecies ortholog to murine Kcnmb4
    homolog to rattus Kcnmb4
    Homologene
    FAMILY
  • KCNMB family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • fundamentally involved in the control of smooth muscle tone and neuronal excitability
  • leading to steeper calcium sensitivity and shifts the voltage range of current activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text calcium-activated potassium channel
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by calcium Ca2+
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS