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FLASH GENE
Symbol RAB26 contributors: mct - updated : 24-03-2017
HGNC name RAB26, member RAS oncogene family
HGNC id 14259
DNA
TYPE functioning gene
STRUCTURE 5.49 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1641 27.8 256 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
 pancreas exocrine   moderately
Nervousbrain   highly
Reproductivemale systemprostate  predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP
HOMOLOGY
interspecies homolog to rattus Rab26 (93.7 pc)
homolog to murine Rab26 (87.5 pc)
Homologene
FAMILY
  • small GTPase superfamily
  • Rab family
  • CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    text
  • intrinsic to plasma membrane
  • lipid-anchor, cytoplasmic side
  • basic FUNCTION
  • participating in exocrine secretion
  • regulating the secretion of acinar granules in the parotid gland
  • involved in regulation of exocytosis
  • important function of RAB26 in coordinating plasma membrane protein transport
  • RAB26, MR1, CCL2, SLC29A4, IBTK, VEGFB, and GOLGA8B may play critical roles in atherosclerotic plaque formation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text
  • exocrine system development
  • PATHWAY
    metabolism
    signaling signal transduction
  • small GTPase mediated signal transduction
  • a component
  • prenylation
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • ATP
  • protein
  • directly and activation-dependently interacted with ADRA2B, specifically the third intracellular loop
  • cell & other
    REGULATION
    induced by BHLHA15 transcription factor (Tian 2010)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS