basic FUNCTION
| involved in endosomes and plasma membrane recycling |
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may relate to inflammation and some kinds of tumor |
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involved in the regulation of intracellular membrane trafficking and reorganization |
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in neuroendocrine cells, acts as a negative regulator of secretory activity, likely by impairing secretory granule transport |
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negatively regulates hormone secretion by interacting with secretory granules, in relation to the altered functioning of tumoral pituitary somatotropes causing acromegaly |
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localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane |
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RAB18 and RAB43, strongly indicated roles in ER-Golgi trafficking |
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has a critical role in human brain and eye development and neurodegeneration |
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involved in insulin-mediated lipogenesis, as well as in beta-adrenergic-induced lipolysis, likely facilitating interaction of lipid droplets with ER membranes and the exchange of lipids between these compartments |
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essential role of Rab proteins potentially in Golgi organization and protein transport |
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RAB18 has likely an important role in viral assembly through the trafficking of the core protein to LDs |
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RAB18 is a critical regulator of neuronal migration and morphogenesis |
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RAB18 modulates autophagy in primary human fibroblasts |
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RAB GTPase RAB18 is a positive modulator of autophagy and is relevant for the maintenance of cellular proteostasis |
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RAB10 and RAB18 were reported to control ER shape by regulating ER dynamics and fusion |
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functions of RAB18 and RAB7A in lysosomal and autophagic activities may constitute an overlapping mechanism underlying WARBM and CMT pathogenesis in the nervous system |
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role for RAB18 in autophagy and regulation of proteostasis in human stellate cells |
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essential role for RAB18 in recruiting ATGL to lipid droplets |
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