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FLASH GENE
Symbol PTDSS2 contributors: KTN/npt - updated : 30/10/2008
HGNC name phosphatidylserine synthase 2
HGNC id 15463
DNA
TYPE functioning gene
STRUCTURE 41.11 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2473 56.1 487 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   moderately
 pancreas exocrine   highly
 salivary gland   predominantly
Endocrineparathyroid   moderately
Nervousnerve   highly
Reproductivemale systemtestis  moderately
Visualeye   highly
cell lineage
cell lines
fluid/secretion highly in blood and lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to dog PTDSS2 (90.7 pc)
homolog to chimpanzee PTDSS2 (97.5 pc)
homolog to rattus Ptdss2 (91.7 pc)
homolog to murine Ptdss2 (92.1 pc)
homolog to chicken PTDSS2 (87.5 pc)
Homologene
FAMILY
  • phosphatidyl serine synthase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • mitochondria-associated membrane
  • multi-pass membrane protein
  • basic FUNCTION
  • catalyzing a base-exchange reaction in which the polar head group of phosphatidylethanolamine is replaced by L-serine
  • acting as a CDP-diacylglycerol-serine O-phosphatidyltransferase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
  • phospholipid metabolism
  • phosphatidylserine biosynthesis
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by excess phosphatidylserine
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS