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FLASH GENE
Symbol PLRG1 contributors: SGE - updated : 30-06-2009
HGNC name pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
HGNC id 9089
DNA
TYPE functioning gene
STRUCTURE 13.86 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 1797 57 514 - Nemeth (1998)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Lymphoid/Immunethymus   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven WD40 domains
  • HOMOLOGY
    interspecies homolog to murine Plrg1 (96.3pc)
    homolog to rattus Plrg1 (96.3pc)
    Homologene
    FAMILY
  • WD-repeat PRL1/PRL2 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text in spliceosome complex
    basic FUNCTION
  • necessary for spliceosome assembly and for pre-mRNA splicing (Ajuh 2003)
  • critical nuclear regulator of p53-dependent cell cycle progression and apoptosis during embryonic development and adult tissue homeostasis (Kleinridders 2009)
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • forms a complex with Pso4/SNEV/Prp19 and CDC5L (Kleinridders 2009)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between the CDC5L protein and PLRG1 in the CDC5L complex essential for pre-mRNA splicing progression
  • interaction between HNRPM and the spliceosome proteins cell division cycle 5-like (CDC5L) and pleiotropic regulator 1 (PLRG1) that was inhibited during the heat-shock stress response
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS