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FLASH GENE
Symbol NLGN3 contributors: mct - updated : 02-07-2012
HGNC name neuroligin 3
HGNC id 14289
DNA
TYPE functioning gene
SPECIAL FEATURE
text putative promoter overlapping the last exon of TNRC11
STRUCTURE 26.37 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 3995 - 848 - 2000 10767552
7 - 3935 - 828 - 2000 10767552
6 - 3875 - 808 - 2000 10767552
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrineadrenal gland   highly
Nervousbrainlimbic systemhippocampus  
 braindiencephalonamygdala  
Reproductivemale systemprostate  highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a alpha/beta-hydrolase fold domain (disease-related mutations in the alpha/beta-hydrolase fold domain share common trafficking deficiencies)
  • HOMOLOGY
    interspecies homolog to rattus Neuroligin
    Homologene
    FAMILY alpha/beta-hydrolase fold family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • potential mediator of cell-cell interactions between neurons
  • triggering presynaptic development in contacting axon and playing a role in synaptic cell adhesion
  • postsynaptic adhesion protein that control the maturation and function of synapses in the central nervous system (CNS)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text formation and remodeling of central nervous system synapses
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with SNTG2 (binding is influenced by autism-related mutations)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ASPGS , AUTSX1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    mental retardation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in Nl3(R451C) mutant mice, a single point mutation in a synaptic cell adhesion molecule causes context-dependent changes in synaptic transmission, and these changes are consistent with the broad impact of this mutation on murine and human behaviors
  • NL-3-deficient mice display a behavioral phenotype reminiscent of the lead symptoms of ASD: reduced ultrasound vocalization and a lack of social novelty preference