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FLASH GENE
Symbol MEPE contributors: mct/npt - updated : 20/12/2008
HGNC name matrix, extracellular phosphoglycoprotein with ASARM motif (bone)
HGNC id 13361
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
text SIBLINGs share many common features, such as their tandem gene location
STRUCTURE 13.80 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - BMP3 - MEPE - D4S1534 - DMP1 - ANXA3 - DSPP - IBSP - SPP1 - BMPR1B - qter
Authors Rowe (00)
regionally located cluster of bone-tooth mineral genes
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1979 - 525 - Ogbureke (2004)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   lowly
 tooth    
Nervousbrain    
Urinarykidneytubuleconvoluted tubuledistal tubulelowly
 kidneytubuleconvoluted tubuleproximal tubulelowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Skeletonosteoblast
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • multiple phosphorylation sites
  • disulfide-free flexible hydrophilic structures
  • presence of the integrin-binding tripeptide, arginine-glycine-aspartate (RGD)
  • a C terminal ASARM, (DSPP/OPN/DMP1) acidic serine-aspartate rich motif
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Mepe
    intraspecies homolog to other bone-tooth mineral matrix phospho-glycoproteins
    Homologene
    FAMILY
  • Small Integrin Binding Ligand N-linked Glycoprotein (SIBLING) family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • involved in phosphate and bone metabolism
  • may be having a role as an early regulator of odontogenic differentiation
  • by direct interaction, decreases CHEK1 from ubiquitin-mediated proteolysis and thus protects cells from DNA damage induced killing (Liu 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text bone mineralization
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • integrin receptor(s)
  • interacting with CHEK1 (Liu 2009)
  • DSPP, MEPE, VCAN, OGN play complementary roles during odontogenesis
  • cell & other
    REGULATION
    Other downregulated by 1.25 (OH)2D3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in oncogenic hypophosphatemic osteomalacia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS