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FLASH GENE
Symbol GANAB contributors: mct - updated : 29-06-2016
HGNC name glucosidase, alpha; neutral AB
HGNC id 4138
DNA
TYPE functioning gene
STRUCTURE 21.90 kb     25 Exon(s)
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 3953 - 963 - 2000 10764837
24 - 3960 107 944 - 2000 10764837
25 - 4026 110 966 - 2000 10764837
21 - 3518 - 830 - 2000 10764837
23 - 3851 - 847 - 2000 10764837
22 - 3684 - 852 - 2000 10764837
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 mouthtongue  highly
Nervousbrain    
Reproductivefemale systemplacenta   
 male systemtestis  highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
Homologene
FAMILY family 31 of glycosyl hydrolases
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,organelle,Golgi
basic FUNCTION
  • hydrolase activity, hydrolyzing O-glycosyl compounds
  • encoding the catalytic subunit of glucosidase II (GIIA)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimer of a catalytic alpha subunit (GANAB) and a beta subunit (PRKCSH)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is required for PKD1 ER exit and maturation (
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PKLD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS