basic FUNCTION
| playing a role in hepatocellular carcinogenesis |
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directly involved in microtubule organization in neuronal cells and may contribute to the pathological phosphorylation of tau in Alzheimer disease |
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MARK1, MARK2, MARK3, MARK4 phosphorylate MAPT in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments |
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is a new negative regulator of MTOR |
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MARK4 kinase activity was required for initiation of axoneme extension 9) |
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is a critical positive regulator of early steps in ciliogenesis |
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MARK1, MARK2, MARK3, MARK4 are implicated in phosphorylation of tau protein, causing formation of neurofibrillary tangles in Alzheimer disease (AD) |
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promotes adipogenesis in adipocytes by activating the MAP2K1 and inhibiting the MAPK14 pathway, and triggers apoptosis by activating the MAP2K1 pathway |
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serine-threonine kinase that phosphorylates MAP proteins, increasing microtubule dynamics |
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MARK2 and MARK4 regulate Sertoli cell blood-testis barrier (BTB) Dynamics through microtubule and actin cytoskeletons |